Insulin-like growth factor-1 in CNS and cerebrovascular aging

William E Sonntag, Ferenc Deak, Nicole Ashpole, Peter Toth, Anna Csiszar, Willard Freeman, Zoltan Ungvari

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades, extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Deficiency in circulating IGF-1 results in impairment in processing speed and deficiencies in both spatial and working memory. Replacement of IGF-1 or factors that increase IGF-1 to old animals and humans reverses many of these cognitive deficits. Despite the overwhelming evidence for IGF-1 as an important neurotrophic agent, the specific mechanisms through which IGF-1 acts have remained elusive. Recent evidence indicates that IGF-1 is both produced by and has important actions on the cerebrovasculature as well as neurons and glia. Nevertheless, the specific regulation and actions of brain- and vascular-derived IGF-1 is poorly understood. The diverse effects of IGF-1 discovered thus far reveal a complex endocrine and paracrine system essential for integrating many of the functions necessary for brain health. Identification of the mechanisms of IGF-1 actions will undoubtedly provide critical insight into regulation of brain function in general and the causes of cognitive decline with age.

Original languageEnglish (US)
Pages (from-to)27
JournalFrontiers in Aging Neuroscience
Volume5
DOIs
StatePublished - 2013

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    Sonntag, W. E., Deak, F., Ashpole, N., Toth, P., Csiszar, A., Freeman, W., & Ungvari, Z. (2013). Insulin-like growth factor-1 in CNS and cerebrovascular aging. Frontiers in Aging Neuroscience, 5, 27. https://doi.org/10.3389/fnagi.2013.00027