Integrating innovative therapeutic strategies into the management of renal cell carcinoma.

Janice P. Dutcher, Waleed Fouad Mourad, Ronald D. Ennis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Three emerging trends have occurred recently in renal cell carcinoma (RCC). First, over the last several decades there has been a marked increase in the diagnosis of RCC, with a corresponding decrease in the typical tumor size, resulting in an increased interest in less invasive approaches to primary tumor treatment. Second, while conventional radiotherapy plays a limited palliative role due to the relative radio-resistance of RCC, advances in immobilization and image guidance have led several investigators to consider stereotactic radiotherapy techniques (SRT) to overcome this resistance, with impressive results in the metastatic setting. In addition, preliminary use of SRT to treat the primary RCC tumor is underway. Thirdly, although RCC is resistant to conventional chemotherapy agents, exciting recent advances have emerged in the treatment of clear cell RCC, with the development of targeted agents in addition to immunotherapy-based treatments. In the current critical review we discuss these emerging trends in localized and systemic treatment as well as possible interesting combinations of the two modalities. Finally, we discuss the role of the new systemic agents in non-clear cell RCC.

Original languageEnglish (US)
JournalONCOLOGY (United States)
Volume26
Issue number6
StatePublished - Jun 1 2012

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Renal Cell Carcinoma
Stereotaxic Techniques
Radiotherapy
Therapeutics
Neoplasms
Radio
Immobilization
Immunotherapy
Research Personnel
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Integrating innovative therapeutic strategies into the management of renal cell carcinoma. / Dutcher, Janice P.; Mourad, Waleed Fouad; Ennis, Ronald D.

In: ONCOLOGY (United States), Vol. 26, No. 6, 01.06.2012.

Research output: Contribution to journalArticle

Dutcher, Janice P. ; Mourad, Waleed Fouad ; Ennis, Ronald D. / Integrating innovative therapeutic strategies into the management of renal cell carcinoma. In: ONCOLOGY (United States). 2012 ; Vol. 26, No. 6.
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