Integrative cardiovascular actions of a novel catecholamine, GP-2-128

G. Abou-Mohamed, Robert William Caldwell, T. M. Ibrahim, R. R. Tuttle

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Systematic modification in the chemical structure of dobutamine resulted in production of a long-acting, highly potent catecholamine, GP-2-128 [(1- (3,4-dihydroxyphenyl)-2-[3-(4-carbamyl phenyl)-1-methyl-propylamino] ethanol)]. The cardiovascular actions of GP-2-128 were compared with those of isoproterenol (ISO) and dobutamine (DOB) in anesthetized dogs. GP-2-128 significantly increased left ventricular pressure (LVdP/dt(max)), cardiac output (CO), and heart rate (HR). It also reduced total peripheral vascular resistance (TPVR). For a given increase in contractility, changes in HR were greater after ISO than after GP-2-128 administration. DOB did not change HR significantly. Both GP-2-128 and DOB reduced TPVR, but ISO was more effective than GP-2-128 and DOB in reducing TPVR. GP-2-128 was 18,000 and 52 times more potent than DOB and ISO, respectively, in increasing LVdP/dt(max). For a given increase in contractility, the cardiovascular actions of GP-2-128 lasted significantly longer than those of DOB or ISO. A 50% mixture of the RR and RS distereoisomer forms of GP-2-128 (GP-2-114) have the same pharmacologic profile as the pure RR distereoisomer. Both GP-2-128 and GP-2- 114 produced current-dependent cardiovascular actions when administered by transdermal iontophoresis. The inotropic and chronotropic effects of GP-2- 128 are both largely due to stimulation of β-adrenoceptors, as shown by receptor blockade with propranolol. GP-2-128 is a very potent, long-acting catecholamine that can be administered by other than intravenous (i.v.) route.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume23
Issue number3
DOIs
StatePublished - Jan 1 1994

Keywords

  • Cardiovascular
  • Dobutamine
  • Dogs
  • GP-2-128
  • Isoproterenol
  • Sympathomimetic amines

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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