TY - JOUR
T1 - Intelligence and academic achievement with asymptomatic congenital cytomegalovirus infection
AU - Lopez, Adriana S.
AU - Lanzieri, Tatiana M.
AU - Claussen, Angelika H.
AU - Vinson, Sherry S.
AU - Turcich, Marie R.
AU - Iovino, Isabella R.
AU - Voigt, Robert G.
AU - Chantal Caviness, A.
AU - Miller, Jerry A.
AU - Daniel Williamson, W.
AU - Hales, Craig M.
AU - Bialek, Stephanie R.
AU - Demmler-Harrison, Gail
N1 - Funding Information:
funding: The study was supported in part by the Cytomegalovirus Research Fund Donors at Baylor College of Medicine; the Woman’s Hospital of Texas Research Foundation; the office of Research Resources and the General Clinical Research Center for Children at Texas Children’s Hospital and Baylor College of Medicine (NIH 5M0I RR00188-33); the Mental Retardation Research Center at Baylor College of Medicine (NIH-CHHD 5 P30 HD24064P); the Research to Prevent Blindness, Inc, New York, New York; the Deafness Foundation, Houston, Texas; the Vale Ashe Foundation, Houston, Texas; the Maddie’s Mission Foundation, Katy, Texas; the Naymola Foundation, Beaumont, Texas; the American Pediatric Society and Society for Pediatric Research Summer Student Research Program (NIH-CHHD); and the Centers for Disease Control and Prevention (Cooperative Agreement FoA IP 10-006). Funded by the National Institutes of Health (NIH).
Publisher Copyright:
Copyright © 2017 by the American Academy of Pediatrics.
PY - 2017/11
Y1 - 2017/11
N2 - OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospitalbased newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing (n = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n = 11) and controls (n = 40). RESULTS: Patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared with controls, but no significant differences were noted in these scores among patients with normal hearing and controls. No significant differences were noted in scores for verbal and nonverbal intelligence, expressive vocabulary, and academic achievement in math and reading among patients with normal hearing or with SNHL and controls. CONCLUSIONS: Infants with asymptomatic congenital cytomegalovirus infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in IQ, vocabulary or academic achievement scores during childhood, or adolescence compared with uninfected children.
AB - OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospitalbased newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing (n = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n = 11) and controls (n = 40). RESULTS: Patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared with controls, but no significant differences were noted in these scores among patients with normal hearing and controls. No significant differences were noted in scores for verbal and nonverbal intelligence, expressive vocabulary, and academic achievement in math and reading among patients with normal hearing or with SNHL and controls. CONCLUSIONS: Infants with asymptomatic congenital cytomegalovirus infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in IQ, vocabulary or academic achievement scores during childhood, or adolescence compared with uninfected children.
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U2 - 10.1542/peds.2017-1517
DO - 10.1542/peds.2017-1517
M3 - Article
C2 - 29066580
AN - SCOPUS:85033555177
VL - 140
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 5
M1 - e20171517
ER -