Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

Li Qin Zhang, Djanybek M. Adyshev, Patrick Singleton, Hailong Li, Javier Cepeda, Sheng You Huang, Xiaoqin Zou, Alexander Dmitriyevich Verin, Jiancheng Tu, Joe G.N. Garcia, Shui Qing Ye

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI. Structured summary: MINT-6538697: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by two hybrid (MI:0018)MINT-6538811, MINT-6538868: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by anti bait coimmunoprecipitation (MI:0006)MINT-6538787, MINT-6538841: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by anti bait coimmunoprecipitation (MI:0006)MINT-6538755: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with γ-glutamyl-transferase (uniprotkb:P19440) by two hybrid (MI:0018)MINT-6538799, MINT-6538862: PBEF (uniprotkb:P43490) physically interacts (MI:0218)with Ferritin light chain (uniprotkb:P02792) by anti bait coimmunoprecipitation (MI:0006)MINT-6538769: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with E2L6 (uniprotkb:O14933) by two hybrid (MI:0018)MINT-6538741: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Adenosine A2aR (uniprotkb:P29274) by two hybrid (MI:0018)MINT-6538727: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by two hybrid (MI:0018)MINT-6538712: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Ferritin light chain (uniprotkb:P02792) by two hybrid (MI:0018).

Original languageEnglish (US)
Pages (from-to)1802-1808
Number of pages7
JournalFEBS Letters
Volume582
Issue number13
DOIs
StatePublished - Jun 11 2008

Fingerprint

Nicotinamide Phosphoribosyltransferase
Oxidative stress
Acute Lung Injury
Staphylococcal Protein A
Heat-Shock Proteins
Oxidative Stress
Apoferritins
NADH Dehydrogenase
Interferons
Rotenone
Endothelial cells

Keywords

  • Acute lung injury
  • Inflammation
  • Interaction
  • Oxidative stress
  • PBEF
  • Vascular permeability

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. / Zhang, Li Qin; Adyshev, Djanybek M.; Singleton, Patrick; Li, Hailong; Cepeda, Javier; Huang, Sheng You; Zou, Xiaoqin; Verin, Alexander Dmitriyevich; Tu, Jiancheng; Garcia, Joe G.N.; Ye, Shui Qing.

In: FEBS Letters, Vol. 582, No. 13, 11.06.2008, p. 1802-1808.

Research output: Contribution to journalArticle

Zhang, LQ, Adyshev, DM, Singleton, P, Li, H, Cepeda, J, Huang, SY, Zou, X, Verin, AD, Tu, J, Garcia, JGN & Ye, SQ 2008, 'Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury', FEBS Letters, vol. 582, no. 13, pp. 1802-1808. https://doi.org/10.1016/j.febslet.2008.04.061
Zhang, Li Qin ; Adyshev, Djanybek M. ; Singleton, Patrick ; Li, Hailong ; Cepeda, Javier ; Huang, Sheng You ; Zou, Xiaoqin ; Verin, Alexander Dmitriyevich ; Tu, Jiancheng ; Garcia, Joe G.N. ; Ye, Shui Qing. / Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. In: FEBS Letters. 2008 ; Vol. 582, No. 13. pp. 1802-1808.
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author = "Zhang, {Li Qin} and Adyshev, {Djanybek M.} and Patrick Singleton and Hailong Li and Javier Cepeda and Huang, {Sheng You} and Xiaoqin Zou and Verin, {Alexander Dmitriyevich} and Jiancheng Tu and Garcia, {Joe G.N.} and Ye, {Shui Qing}",
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T1 - Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

AU - Zhang, Li Qin

AU - Adyshev, Djanybek M.

AU - Singleton, Patrick

AU - Li, Hailong

AU - Cepeda, Javier

AU - Huang, Sheng You

AU - Zou, Xiaoqin

AU - Verin, Alexander Dmitriyevich

AU - Tu, Jiancheng

AU - Garcia, Joe G.N.

AU - Ye, Shui Qing

PY - 2008/6/11

Y1 - 2008/6/11

N2 - Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI. Structured summary: MINT-6538697: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by two hybrid (MI:0018)MINT-6538811, MINT-6538868: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by anti bait coimmunoprecipitation (MI:0006)MINT-6538787, MINT-6538841: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by anti bait coimmunoprecipitation (MI:0006)MINT-6538755: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with γ-glutamyl-transferase (uniprotkb:P19440) by two hybrid (MI:0018)MINT-6538799, MINT-6538862: PBEF (uniprotkb:P43490) physically interacts (MI:0218)with Ferritin light chain (uniprotkb:P02792) by anti bait coimmunoprecipitation (MI:0006)MINT-6538769: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with E2L6 (uniprotkb:O14933) by two hybrid (MI:0018)MINT-6538741: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Adenosine A2aR (uniprotkb:P29274) by two hybrid (MI:0018)MINT-6538727: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by two hybrid (MI:0018)MINT-6538712: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Ferritin light chain (uniprotkb:P02792) by two hybrid (MI:0018).

AB - Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI. Structured summary: MINT-6538697: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by two hybrid (MI:0018)MINT-6538811, MINT-6538868: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by anti bait coimmunoprecipitation (MI:0006)MINT-6538787, MINT-6538841: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with NADH1 (uniprotkb:P03886) by anti bait coimmunoprecipitation (MI:0006)MINT-6538755: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with γ-glutamyl-transferase (uniprotkb:P19440) by two hybrid (MI:0018)MINT-6538799, MINT-6538862: PBEF (uniprotkb:P43490) physically interacts (MI:0218)with Ferritin light chain (uniprotkb:P02792) by anti bait coimmunoprecipitation (MI:0006)MINT-6538769: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with E2L6 (uniprotkb:O14933) by two hybrid (MI:0018)MINT-6538741: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Adenosine A2aR (uniprotkb:P29274) by two hybrid (MI:0018)MINT-6538727: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with interferon-induced transmembrane protein 3 (uniprotkb:Q01628) by two hybrid (MI:0018)MINT-6538712: PBEF (uniprotkb:P43490) physically interacts (MI:0218) with Ferritin light chain (uniprotkb:P02792) by two hybrid (MI:0018).

KW - Acute lung injury

KW - Inflammation

KW - Interaction

KW - Oxidative stress

KW - PBEF

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