Interactive influences of ethnicity, endothelin-1 gene, and everyday discrimination upon nocturnal ambulatory blood pressure

Mathew J. Gregoski, Sarah G. Buxbaum, Kakota Gaston Kapuku, Yanbin Dong, Haidong Zhu, Mary Davis, Kelsey Gonto, Frank A. Treiber

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Everyday discrimination scale scores are associated with increased ambulatory blood pressure (BP) and reduced nocturnal dipping, and the endothelin-1 (ET-1)/Lys198Asn polymorphism is associated with increased resting BP and exaggerated BP reactivity among African Americans compared to European Americans. Combined influences of these factors on BP control are unknown. Purpose: This study tested the hypothesis of a three-way interaction between ethnicity, ET-1 carrier status, and everyday discrimination upon ambulatory BP and nocturnal dipping. Methods: Baseline laboratory anthropometrics and the everyday discrimination scale were completed by 352 (175 African American) young adult normotensives, followed by 24-h ambulatory BP monitoring. Results: For nocturnal dipping, multiple regression models controlling for age, sex, ethnicity, and body mass index revealed significant three-way ET-1 × everyday discrimination × ethnicity interactions. Specifically, among African American ET-1 T-allele carriers, increases in everyday discrimination led to reduced nocturnal dipping. Conclusions: African Americans that carry the ET-1/Lys198Asn T-allele and report higher everyday discrimination scores may be at particular risk for reduced nocturnal dipping.

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalAnnals of Behavioral Medicine
Volume45
Issue number3
DOIs
StatePublished - Jun 1 2013

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Endothelin-1
African Americans
Blood Pressure
Genes
Alleles
Ambulatory Blood Pressure Monitoring
Young Adult
Body Mass Index

Keywords

  • African American
  • ET-1 polymorphism
  • Everyday discrimination
  • Nocturnal dipping

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Interactive influences of ethnicity, endothelin-1 gene, and everyday discrimination upon nocturnal ambulatory blood pressure. / Gregoski, Mathew J.; Buxbaum, Sarah G.; Kapuku, Kakota Gaston; Dong, Yanbin; Zhu, Haidong; Davis, Mary; Gonto, Kelsey; Treiber, Frank A.

In: Annals of Behavioral Medicine, Vol. 45, No. 3, 01.06.2013, p. 377-386.

Research output: Contribution to journalArticle

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AU - Zhu, Haidong

AU - Davis, Mary

AU - Gonto, Kelsey

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