Interactive influences of ethnicity, endothelin-1 gene, and everyday discrimination upon nocturnal ambulatory blood pressure

Mathew J. Gregoski, Sarah G. Buxbaum, Gaston Kapuku, Yanbin Dong, Haidong Zhu, Mary Davis, Kelsey Gonto, Frank A. Treiber

Research output: Contribution to journalArticle

14 Scopus citations


Background: Everyday discrimination scale scores are associated with increased ambulatory blood pressure (BP) and reduced nocturnal dipping, and the endothelin-1 (ET-1)/Lys198Asn polymorphism is associated with increased resting BP and exaggerated BP reactivity among African Americans compared to European Americans. Combined influences of these factors on BP control are unknown. Purpose: This study tested the hypothesis of a three-way interaction between ethnicity, ET-1 carrier status, and everyday discrimination upon ambulatory BP and nocturnal dipping. Methods: Baseline laboratory anthropometrics and the everyday discrimination scale were completed by 352 (175 African American) young adult normotensives, followed by 24-h ambulatory BP monitoring. Results: For nocturnal dipping, multiple regression models controlling for age, sex, ethnicity, and body mass index revealed significant three-way ET-1 × everyday discrimination × ethnicity interactions. Specifically, among African American ET-1 T-allele carriers, increases in everyday discrimination led to reduced nocturnal dipping. Conclusions: African Americans that carry the ET-1/Lys198Asn T-allele and report higher everyday discrimination scores may be at particular risk for reduced nocturnal dipping.

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalAnnals of Behavioral Medicine
Issue number3
Publication statusPublished - Jun 1 2013



  • African American
  • ET-1 polymorphism
  • Everyday discrimination
  • Nocturnal dipping

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

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