Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure

Arjun Sinha, Avni Bavishi, Elizabeth A. Hibler, Eric H. Yang, Susmita Parashar, Tochukwu Okwuosa, Jeanne M. DeCara, Sherry Ann Brown, Avirup Guha, Diego Sadler, Sadiya S. Khan, Sanjiv J. Shah, Clyde W. Yancy, Nausheen Akhter

Research output: Contribution to journalReview articlepeer-review

Abstract

Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.

Original languageEnglish (US)
Article number847975
JournalFrontiers in Cardiovascular Medicine
Volume9
DOIs
StatePublished - May 20 2022

Keywords

  • breast cancer
  • heart failure
  • reverse cardio-oncology
  • risk factors
  • social determinants of health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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