Interleukin-2 receptor targeted therapy of ocular disease of HTLV-1-associated adult T-cell leukemia

Theresa A. Larson, Mengjun Hu, John Edward Janik, Robert B. Nussenblatt, John C. Morris, H. Nida Sen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To report two cases of patients with ocular manifestations of human T-cell lymphotropic virus type-1 (HTLV-1) associated adult T-cell leukemia/lymphoma (ATL) who were successfully treated with interleukin-2 receptor targeted therapies. Method: Case series. Results: Two patients with HTLV-1-associated ATL developed symptomatic scleritis. In the first case, conjunctival biopsy showed leukemic infiltration that was confirmed by T-cell receptor polymerase chain reaction (PCR) demonstrating a clonal rearrangement. As treatment for ATL, both cases received interleukin-2 receptor targeted therapy. In one patient, daclizumab, a monoclonal antibody directed against the alpha chain of the interleukin-2 (IL-2) receptor, was used. The second patient was treated with denileukin diftitox, an immunotoxin fusion protein that targets the IL-2 receptor. Improvement in scleritis was noted in both patients. Conclusion: Scleritis in patients with underlying HTLV-1-associated ATL is responsive to IL-2 receptor targeted therapies.

Original languageEnglish (US)
Pages (from-to)312-314
Number of pages3
JournalOcular Immunology and Inflammation
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2012

Keywords

  • Adult T-cell leukemia/lymphoma
  • Daclizumab
  • Denileukin diftitox
  • Human T-cell lymphotropic virus type-1
  • Scleritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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