TY - JOUR
T1 - Intermuscular adipose tissue in Type 2 diabetes mellitus
T2 - Non-invasive quantitative imaging and clinical implications
AU - Yu, Fuyao
AU - Fan, Yiping
AU - Sun, He
AU - Li, Tianming
AU - Dong, Yanbin
AU - Pan, Shinong
N1 - Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2022/5
Y1 - 2022/5
N2 - Intermuscular adipose tissue (IMAT) is an ectopic fat depot found beneath the fascia and within the muscles. IMAT modulates muscle insulin sensitivity and triggers local and systemic chronic low-grade inflammation by producing cytokines and chemokines, which underlie the pathogenesis of Type 2 diabetes mellitus (T2DM). Imaging techniques have been increasingly used to non-invasively quantify IMAT in patients with diabetes in research and healthcare settings. In this study, we systematically reviewed the cell of origin and definition of IMAT, and the use of quantitative and functional imaging technology pertinent to the etiology, risk factors, lifestyle modification, and therapeutic treatment of diabetes. The purpose of this article is to provide important insight into the current understanding of IMAT and future prospects of targeting IMAT for T2DM control.
AB - Intermuscular adipose tissue (IMAT) is an ectopic fat depot found beneath the fascia and within the muscles. IMAT modulates muscle insulin sensitivity and triggers local and systemic chronic low-grade inflammation by producing cytokines and chemokines, which underlie the pathogenesis of Type 2 diabetes mellitus (T2DM). Imaging techniques have been increasingly used to non-invasively quantify IMAT in patients with diabetes in research and healthcare settings. In this study, we systematically reviewed the cell of origin and definition of IMAT, and the use of quantitative and functional imaging technology pertinent to the etiology, risk factors, lifestyle modification, and therapeutic treatment of diabetes. The purpose of this article is to provide important insight into the current understanding of IMAT and future prospects of targeting IMAT for T2DM control.
KW - Exercise
KW - Intermuscular adipose tissue
KW - Muscle
KW - Type 2 diabetes mellitus
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U2 - 10.1016/j.diabres.2022.109881
DO - 10.1016/j.diabres.2022.109881
M3 - Article
C2 - 35483545
AN - SCOPUS:85129098120
SN - 0168-8227
VL - 187
SP - 109881
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 109881
ER -