Intermuscular adipose tissue in Type 2 diabetes mellitus: Non-invasive quantitative imaging and clinical implications

Fuyao Yu, Yiping Fan, He Sun, Tianming Li, Yanbin Dong, Shinong Pan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Intermuscular adipose tissue (IMAT) is an ectopic fat depot found beneath the fascia and within the muscles. IMAT modulates muscle insulin sensitivity and triggers local and systemic chronic low-grade inflammation by producing cytokines and chemokines, which underlie the pathogenesis of Type 2 diabetes mellitus (T2DM). Imaging techniques have been increasingly used to non-invasively quantify IMAT in patients with diabetes in research and healthcare settings. In this study, we systematically reviewed the cell of origin and definition of IMAT, and the use of quantitative and functional imaging technology pertinent to the etiology, risk factors, lifestyle modification, and therapeutic treatment of diabetes. The purpose of this article is to provide important insight into the current understanding of IMAT and future prospects of targeting IMAT for T2DM control.

Original languageEnglish (US)
Article number109881
Pages (from-to)109881
JournalDiabetes Research and Clinical Practice
Volume187
DOIs
StatePublished - May 2022

Keywords

  • Exercise
  • Intermuscular adipose tissue
  • Muscle
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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