Intracranial stimulation study of lateralization of affect

Joseph R. Smith, Gregory P Lee, Kostas Fountas, Don W. King, Patrick D. Jenkins

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P = 0.01) with right-sided stimulation (N = 18) as compared with left-sided stimulation (N = 3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalEpilepsy and Behavior
Volume8
Issue number3
DOIs
StatePublished - May 1 2006

Fingerprint

Fear
Epilepsy
Electrodes
Language

Keywords

  • Depth electrodes
  • Dysphoric responses
  • Euphoric responses
  • Subdural electrodes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Smith, J. R., Lee, G. P., Fountas, K., King, D. W., & Jenkins, P. D. (2006). Intracranial stimulation study of lateralization of affect. Epilepsy and Behavior, 8(3), 534-541. https://doi.org/10.1016/j.yebeh.2005.12.014

Intracranial stimulation study of lateralization of affect. / Smith, Joseph R.; Lee, Gregory P; Fountas, Kostas; King, Don W.; Jenkins, Patrick D.

In: Epilepsy and Behavior, Vol. 8, No. 3, 01.05.2006, p. 534-541.

Research output: Contribution to journalArticle

Smith, JR, Lee, GP, Fountas, K, King, DW & Jenkins, PD 2006, 'Intracranial stimulation study of lateralization of affect', Epilepsy and Behavior, vol. 8, no. 3, pp. 534-541. https://doi.org/10.1016/j.yebeh.2005.12.014
Smith, Joseph R. ; Lee, Gregory P ; Fountas, Kostas ; King, Don W. ; Jenkins, Patrick D. / Intracranial stimulation study of lateralization of affect. In: Epilepsy and Behavior. 2006 ; Vol. 8, No. 3. pp. 534-541.
@article{d58a10a343984945b2aa759937b07ce7,
title = "Intracranial stimulation study of lateralization of affect",
abstract = "As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P = 0.01) with right-sided stimulation (N = 18) as compared with left-sided stimulation (N = 3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.",
keywords = "Depth electrodes, Dysphoric responses, Euphoric responses, Subdural electrodes",
author = "Smith, {Joseph R.} and Lee, {Gregory P} and Kostas Fountas and King, {Don W.} and Jenkins, {Patrick D.}",
year = "2006",
month = "5",
day = "1",
doi = "10.1016/j.yebeh.2005.12.014",
language = "English (US)",
volume = "8",
pages = "534--541",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Intracranial stimulation study of lateralization of affect

AU - Smith, Joseph R.

AU - Lee, Gregory P

AU - Fountas, Kostas

AU - King, Don W.

AU - Jenkins, Patrick D.

PY - 2006/5/1

Y1 - 2006/5/1

N2 - As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P = 0.01) with right-sided stimulation (N = 18) as compared with left-sided stimulation (N = 3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.

AB - As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P = 0.01) with right-sided stimulation (N = 18) as compared with left-sided stimulation (N = 3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.

KW - Depth electrodes

KW - Dysphoric responses

KW - Euphoric responses

KW - Subdural electrodes

UR - http://www.scopus.com/inward/record.url?scp=33646100752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646100752&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2005.12.014

DO - 10.1016/j.yebeh.2005.12.014

M3 - Article

VL - 8

SP - 534

EP - 541

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 3

ER -