Intracranial stimulation study of lateralization of affect

Joseph R. Smith, Gregory P Lee, Kostas Fountas, Don W. King, Patrick D. Jenkins

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

As part of their evaluation for epilepsy surgery, 53 patients underwent stimulation of depth or subdural electrodes. Responses obtained from depth stimulation included motor responses at 34 sites, sensory responses at 114 sites, language alterations at 6 sites, and affective responses at 22 sites. Responses obtained from subdural stimulation included motor responses at 19 sites, sensory responses at 31 sites, speech alterations at 10 sites, and affective responses at 1 site. Of 23 affective responses, 21 were dysphoric responses of fear, a sense of dying, or unpleasantness with or without some type of experiential phenomenon. Dysphoric responses were statistically associated (P = 0.01) with right-sided stimulation (N = 18) as compared with left-sided stimulation (N = 3) of mesial frontal, orbitofrontal, mesial temporal, and insular stimulation sites. Two euphoric responses occurred, one with left-sided and one with right-sided stimulation. No affective responses were obtained with convexity or neocortical stimulation.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalEpilepsy and Behavior
Volume8
Issue number3
DOIs
StatePublished - May 1 2006

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Keywords

  • Depth electrodes
  • Dysphoric responses
  • Euphoric responses
  • Subdural electrodes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Smith, J. R., Lee, G. P., Fountas, K., King, D. W., & Jenkins, P. D. (2006). Intracranial stimulation study of lateralization of affect. Epilepsy and Behavior, 8(3), 534-541. https://doi.org/10.1016/j.yebeh.2005.12.014