Intraoperative monitoring of heparin: Comparison of activated coagulation time and whole blood heparin measurements by different point-of-care devices with heparin concentration by laboratory-performed plasma anti-Xa assay

Thomas Z. Thompson, Rebecca L. Kunak, Natasha M. Savage, Shvetank Agarwal, Jennifer Chazelle, Gurmukh Singh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Cardiac surgical interventions, extracorporeal membrane oxygenation, transcutaneous coronary-artery angioplasty, and stenting are carried out while patients are being treated with the anticoagulation drug heparin. Monitoring the level and reversal of heparinization during and at the conclusion of medical and surgical procedures is a critical issue in patient care. Methods: We performed parallel testing of the ACCRIVA Hemochron Signature Elite ACT+ and Hemochron Response analyzer, iSTAT platform, and 2 Hepcon Hemostasis Management System (HMS) Plus analyzers for monitoring intraoperative heparin treatment. Laboratory anti-Xa assay was used as the criterion standard for heparin measurement. Results: Poor correlation between the 2 Hemochron analyzers was identified at 0.78. Correlation between the analyzers on the i-STAT platform was 0.97. Regression analysis revealed that i-STAT values were generally lower, by 43 seconds, than Hemochron values. The correlation between Hepcon and i-STAT activated clotting time (ACT) results was 0.94. The i-STAT ACT results were generally 23 seconds lower than the Hepcon ACT values. Correlation coefficients on comparing Hepcon ACT and i-STAT ACT using laboratory anti-Xa assay were 0.83 and 0.87, respectively. The correlation between Hepcon heparin concentration and anti-Xa results was 0.85. Conclusions: ACT monitoring with iSTAT offers good correlation between instruments and with the Hepcon ACT. Hepcon occupies a specific niche in cardiac operating departments because of its ability to provide additional information regarding heparin concentration; however, lack of suitable proficiency testing may impair its use. The iSTAT is a more reliable platform for broader, hospital-wide application.

Original languageEnglish (US)
Pages (from-to)348-356
Number of pages9
JournalLab Medicine
Volume50
Issue number4
DOIs
StatePublished - Jan 1 2019

Keywords

  • ACT
  • Hemochron
  • Heparin
  • Hepcon
  • I-STAT
  • Point-of-care

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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