Intratubular embryonal carcinoma: A report of 2 cases

Dinesh Rakheja, Mai P. Hoang, Suash Sharma, Jorge Albores-Saavedra

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Abstract

Although intratubular embryonal carcinoma has been described adjacent to invasive embryonal carcinoma, to our knowledge it has not been reported as an isolated finding. We present in this report the histologic and immunohistochemical findings of 2 cases of intratubular embryonal carcinoma. One case was exclusively intratubular embryonal carcinoma without an invasive component in the same testis. A malignant mixed germ cell tumor in the contralateral testis had been previously excised. The second case is predominantly composed of intratubular embryonal carcinoma adjacent to a malignant mixed germ cell tumor. In one case, the intratubular embryonal carcinoma was immunoreactive for CD30, AE1/AE3, cytokeratin 7 focally, and p53. It was negative for cytokeratin 20, p21, and α-fetoprotein. These findings are strongly supportive of the opinion that intratubular embryonal carcinoma is the precursor of invasive embryonal carcinoma.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume126
Issue number4
StatePublished - Apr 17 2002

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Rakheja, D., Hoang, M. P., Sharma, S., & Albores-Saavedra, J. (2002). Intratubular embryonal carcinoma: A report of 2 cases. Archives of Pathology and Laboratory Medicine, 126(4), 487-490.