Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries

Mark W. Wilson, R. Clinton Webb, M. Victoria Marx, Charles R. Meyer, Marsha A. Gallagher, Staci L. Haarer, Andrew J. Buda, David M. Williams

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P < .001): –5.2% with 10–8 M serotonin, –15% with 10–7 M, and –28% with 10–6 M. Historically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalInvestigative Radiology
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Blood Vessels
Canidae
Ultrasonography
Serotonin
Arteries
External Carotid Artery
Iliac Artery
Common Carotid Artery
Femoral Artery
Thigh
Baths
Carotid Arteries
Catheters
Salts
Injections

Keywords

  • Canine arteries
  • Elastin
  • Intravascular ultrasound imaging
  • Serotonin
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wilson, M. W., Webb, R. C., Marx, M. V., Meyer, C. R., Gallagher, M. A., Haarer, S. L., ... Williams, D. M. (1991). Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries. Investigative Radiology, 26(3), 248-253. https://doi.org/10.1097/00004424-199103000-00010

Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries. / Wilson, Mark W.; Webb, R. Clinton; Marx, M. Victoria; Meyer, Charles R.; Gallagher, Marsha A.; Haarer, Staci L.; Buda, Andrew J.; Williams, David M.

In: Investigative Radiology, Vol. 26, No. 3, 01.01.1991, p. 248-253.

Research output: Contribution to journalArticle

Wilson, MW, Webb, RC, Marx, MV, Meyer, CR, Gallagher, MA, Haarer, SL, Buda, AJ & Williams, DM 1991, 'Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries', Investigative Radiology, vol. 26, no. 3, pp. 248-253. https://doi.org/10.1097/00004424-199103000-00010
Wilson, Mark W. ; Webb, R. Clinton ; Marx, M. Victoria ; Meyer, Charles R. ; Gallagher, Marsha A. ; Haarer, Staci L. ; Buda, Andrew J. ; Williams, David M. / Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries. In: Investigative Radiology. 1991 ; Vol. 26, No. 3. pp. 248-253.
@article{033b52add15046669fd9c892dc0bfbc6,
title = "Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries",
abstract = "We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P < .001): –5.2{\%} with 10–8 M serotonin, –15{\%} with 10–7 M, and –28{\%} with 10–6 M. Historically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.",
keywords = "Canine arteries, Elastin, Intravascular ultrasound imaging, Serotonin, Vascular smooth muscle",
author = "Wilson, {Mark W.} and Webb, {R. Clinton} and Marx, {M. Victoria} and Meyer, {Charles R.} and Gallagher, {Marsha A.} and Haarer, {Staci L.} and Buda, {Andrew J.} and Williams, {David M.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1097/00004424-199103000-00010",
language = "English (US)",
volume = "26",
pages = "248--253",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries

AU - Wilson, Mark W.

AU - Webb, R. Clinton

AU - Marx, M. Victoria

AU - Meyer, Charles R.

AU - Gallagher, Marsha A.

AU - Haarer, Staci L.

AU - Buda, Andrew J.

AU - Williams, David M.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P < .001): –5.2% with 10–8 M serotonin, –15% with 10–7 M, and –28% with 10–6 M. Historically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.

AB - We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P < .001): –5.2% with 10–8 M serotonin, –15% with 10–7 M, and –28% with 10–6 M. Historically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.

KW - Canine arteries

KW - Elastin

KW - Intravascular ultrasound imaging

KW - Serotonin

KW - Vascular smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=0026024174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026024174&partnerID=8YFLogxK

U2 - 10.1097/00004424-199103000-00010

DO - 10.1097/00004424-199103000-00010

M3 - Article

C2 - 2055730

AN - SCOPUS:0026024174

VL - 26

SP - 248

EP - 253

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 3

ER -