Intravitreal Ceftriaxone in a Rabbit Model: Dose- and Time-Dependent Toxic Effects and Pharmacokinetic Analysis

Robert K. Shockley, Walter M. Jay, Thomas R. Friberg, Adel M. Aziz, J. Peter Rissing, Mervat Z. Aziz

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Abstract

Ceftriaxone's toxic effects were assessed in albino rabbits after intravitreal injection. Doses up to 5 mg did not alter the B-wave amplitude. Following 7.5-and 20-mg doses, B-wave amplitude ratios were depressed at 24 hours and normal at seven and 14 days. A 50-mg dose caused a temporarily flat B-wave 24 hours after injection. At two weeks this ratio exhibited a moderate increase but remained 2 SDs below the mean preinjection ratio. Eyes receiving up to 20 mg were normal histologically at 14 days. A 50-mg dose induced generalized retinal edema and disruption of the retinal layers 24 hours after injection; at two weeks there were no histologic changes in the retina. Immediately after a 2-mg intravitreal injection, vitreous ceftriaxone levels were 1,345 ± 4.9 mg/L; by 72 hours they had decreased to 17.6 ± 1.4 mg/L. The mean peak aqueous level was 80.2 ± 12.2 mg/L at 72 hours.

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalArchives of Ophthalmology
Volume102
Issue number8
DOIs
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Ophthalmology

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