Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide

James I. Koenigt, Kenneth Snow, Burton D. Clark, Roberto Toni, Joseph G. Cannon, Alan R. Shaw, Charles A. Dinarello, Seymour Reichlin, Stephanie L. Lee, Ronald M. Lechan

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

Original languageEnglish (US)
Pages (from-to)3053
Number of pages1
JournalEndocrinology
Volume126
Issue number6
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide'. Together they form a unique fingerprint.

  • Cite this

    Koenigt, J. I., Snow, K., Clark, B. D., Toni, R., Cannon, J. G., Shaw, A. R., Dinarello, C. A., Reichlin, S., Lee, S. L., & Lechan, R. M. (1990). Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. Endocrinology, 126(6), 3053. https://doi.org/10.1210/endo-126-6-3053