Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide

James I. Koenigt; Kenneth Snow; Burton D. Clark; Roberto Toni; Joseph G. Cannon; Alan R. Shaw; Charles A. Dinarello; Seymour Reichlin; Stephanie L. Lee; Ronald M. Lechan

doi:10.1210/endo-126-6-3053

Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide

James I. Koenigt, Kenneth Snow, Burton D. Clark, Roberto Toni, Joseph G. Cannon, Alan R. Shaw, Charles A. Dinarello, Seymour Reichlin, Stephanie L. Lee, Ronald M. Lechan

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Article

153 Scopus citations

Abstract

Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

Original language	English (US)
Pages (from-to)	3053
Number of pages	1
Journal	Endocrinology
Volume	126
Issue number	6
DOIs	https://doi.org/10.1210/endo-126-6-3053
State	Published - Jun 1990

ASJC Scopus subject areas

Endocrinology

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Koenigt, J. I., Snow, K., Clark, B. D., Toni, R., Cannon, J. G., Shaw, A. R., Dinarello, C. A., Reichlin, S., Lee, S. L., & Lechan, R. M. (1990). Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. Endocrinology, 126(6), 3053. https://doi.org/10.1210/endo-126-6-3053

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abstract = "Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.",

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AU - Dinarello, Charles A.

AU - Reichlin, Seymour

AU - Lee, Stephanie L.

AU - Lechan, Ronald M.

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