Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide

James I. Koenigt, Kenneth Snow, Burton D. Clark, Roberto Toni, Joseph Gerard Cannon, Alan R. Shaw, Charles A. Dinarello, Seymour Reichlin, Stephanie L. Lee, Ronald M. Lechan

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

Original languageEnglish (US)
Number of pages1
JournalEndocrinology
Volume126
Issue number6
DOIs
StatePublished - Jan 1 1990

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Interleukins
Interleukin-1
Lipopolysaccharides
Cytoplasmic Granules
Complementary RNA
Endocrine Cells
Northern Blotting
Immune Sera
Spleen
Messenger RNA

ASJC Scopus subject areas

  • Endocrinology

Cite this

Koenigt, J. I., Snow, K., Clark, B. D., Toni, R., Cannon, J. G., Shaw, A. R., ... Lechan, R. M. (1990). Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. Endocrinology, 126(6). https://doi.org/10.1210/endo-126-6-3053

Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. / Koenigt, James I.; Snow, Kenneth; Clark, Burton D.; Toni, Roberto; Cannon, Joseph Gerard; Shaw, Alan R.; Dinarello, Charles A.; Reichlin, Seymour; Lee, Stephanie L.; Lechan, Ronald M.

In: Endocrinology, Vol. 126, No. 6, 01.01.1990.

Research output: Contribution to journalArticle

Koenigt, JI, Snow, K, Clark, BD, Toni, R, Cannon, JG, Shaw, AR, Dinarello, CA, Reichlin, S, Lee, SL & Lechan, RM 1990, 'Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide', Endocrinology, vol. 126, no. 6. https://doi.org/10.1210/endo-126-6-3053
Koenigt JI, Snow K, Clark BD, Toni R, Cannon JG, Shaw AR et al. Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. Endocrinology. 1990 Jan 1;126(6). https://doi.org/10.1210/endo-126-6-3053
Koenigt, James I. ; Snow, Kenneth ; Clark, Burton D. ; Toni, Roberto ; Cannon, Joseph Gerard ; Shaw, Alan R. ; Dinarello, Charles A. ; Reichlin, Seymour ; Lee, Stephanie L. ; Lechan, Ronald M. / Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. In: Endocrinology. 1990 ; Vol. 126, No. 6.
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