Abstract
Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.
| Original language | English (US) |
|---|---|
| Number of pages | 1 |
| Journal | Endocrinology |
| Volume | 126 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1990 |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide. / Koenigt, James I.; Snow, Kenneth; Clark, Burton D.; Toni, Roberto; Cannon, Joseph G.; Shaw, Alan R.; Dinarello, Charles A.; Reichlin, Seymour; Lee, Stephanie L.; Lechan, Ronald M.
In: Endocrinology, Vol. 126, No. 6, 06.1990.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intrinsic pituitary interleukin-lβ is induced by bacterial lipopolysaccharide
AU - Koenigt, James I.
AU - Snow, Kenneth
AU - Clark, Burton D.
AU - Toni, Roberto
AU - Cannon, Joseph G.
AU - Shaw, Alan R.
AU - Dinarello, Charles A.
AU - Reichlin, Seymour
AU - Lee, Stephanie L.
AU - Lechan, Ronald M.
PY - 1990/6
Y1 - 1990/6
N2 - Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.
AB - Using a specific antiserum recognizing recombinant rat interleukin-1β (IL-1β), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1β cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1β message after the administration of bacterial lipopolysaccharide, raises the possibility thatIL-1β may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.
UR - http://www.scopus.com/inward/record.url?scp=0025285732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025285732&partnerID=8YFLogxK
U2 - 10.1210/endo-126-6-3053
DO - 10.1210/endo-126-6-3053
M3 - Article
C2 - 2190803
AN - SCOPUS:0025285732
VL - 126
JO - Endocrinology
JF - Endocrinology
SN - 0013-7227
IS - 6
ER -