Introduction of histidine units using benzotriazolide activation

Siva S Panda

doi:10.1002/psc.2483

Introduction of histidine units using benzotriazolide activation

Siva S Panda

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.

Original language	English (US)
Pages (from-to)	110-7
Number of pages	8
Journal	Journal of Peptide Science
Volume	19
Issue number	2
DOIs	https://doi.org/10.1002/psc.2483
State	Published - Feb 2013

Keywords

Histidine
Molecular Structure
Oligopeptides
Tosyl Compounds
Triazoles
Journal Article
Research Support, Non-U.S. Gov't

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10.1002/psc.2483

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title = "Introduction of histidine units using benzotriazolide activation",

abstract = "N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.",

keywords = "Histidine, Molecular Structure, Oligopeptides, Tosyl Compounds, Triazoles, Journal Article, Research Support, Non-U.S. Gov't",

author = "Panda, {Siva S}",

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year = "2013",

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AB - N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.

KW - Histidine

KW - Molecular Structure

KW - Oligopeptides

KW - Tosyl Compounds

KW - Triazoles

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/psc.2483

DO - 10.1002/psc.2483

M3 - Article

C2 - 23322621

SN - 1075-2617

VL - 19

SP - 110

EP - 117

JO - Journal of Peptide Science

JF - Journal of Peptide Science

IS - 2

ER -

Introduction of histidine units using benzotriazolide activation

Abstract

Keywords

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