Introduction of histidine units using benzotriazolide activation

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.

Original languageEnglish (US)
Pages (from-to)110-7
Number of pages8
JournalJournal of Peptide Science
Volume19
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Histidine
Chemical activation
Acylation
Nucleophiles
Peptides

Keywords

  • Histidine
  • Molecular Structure
  • Oligopeptides
  • Tosyl Compounds
  • Triazoles
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Introduction of histidine units using benzotriazolide activation. / Panda, Siva S.

In: Journal of Peptide Science, Vol. 19, No. 2, 02.2013, p. 110-7.

Research output: Contribution to journalArticle

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KW - Histidine

KW - Molecular Structure

KW - Oligopeptides

KW - Tosyl Compounds

KW - Triazoles

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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