Abstract
Despite the potential detrimental effects of systemic inflammation on muscle mass, which is mainly observed in patients with pathologic diseases, its role in muscle strength, especially in a healthy general population reflecting subclinical low-grade inflammation, is unclear. This is a nationally representative population-based, cross-sectional study from the Korea National Health and Nutrition Examination Survey, which enrolled 1,036 men aged ≥50 years and 1,080 postmenopausal women. After adjustment for confounders, serum highsensitivity C-reactive protein (hsCRP) level was inversely associated with hand grip strength (HGS) in men. Consistently, compared with men in the lowest serum hsCRP quartile, those in the highest quartile showed a significant lower HGS, with a linear decrease of HGS across increasing serum hsCRP quartiles. Men with low muscle strength had 74.2% higher serum hsCRP than those without, and each standard deviation increment in serum hsCRP was associated with a multivariate-adjusted odds ratio of 1.35 for the risk of low muscle strength in men. However, these associations were not statistically significant in women. These findings provide clinical evidence that chronic subclinical low-grade inflammation may contribute to the deterioration of muscle strength seen with aging, especially in men.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2051-2061 |
| Number of pages | 11 |
| Journal | Aging |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2018 |
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Keywords
- Hand grip strength
- High sensitivity C-reactive protein
- Inflammation
- Muscle strength
- Sarcopenia
ASJC Scopus subject areas
- Aging
- Cell Biology
Cite this
Inverse relationship between serum hsCRP concentration and hand grip strength in older adults : A nationwide population-based study. / Kim, Beom Jun; Lee, Seung Hun; Kwak, Mi Kyung; Isales, Carlos M; Koh, Jung Min; Hamrick, Mark W.
In: Aging, Vol. 10, No. 8, 01.08.2018, p. 2051-2061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inverse relationship between serum hsCRP concentration and hand grip strength in older adults
T2 - A nationwide population-based study
AU - Kim, Beom Jun
AU - Lee, Seung Hun
AU - Kwak, Mi Kyung
AU - Isales, Carlos M
AU - Koh, Jung Min
AU - Hamrick, Mark W
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Despite the potential detrimental effects of systemic inflammation on muscle mass, which is mainly observed in patients with pathologic diseases, its role in muscle strength, especially in a healthy general population reflecting subclinical low-grade inflammation, is unclear. This is a nationally representative population-based, cross-sectional study from the Korea National Health and Nutrition Examination Survey, which enrolled 1,036 men aged ≥50 years and 1,080 postmenopausal women. After adjustment for confounders, serum highsensitivity C-reactive protein (hsCRP) level was inversely associated with hand grip strength (HGS) in men. Consistently, compared with men in the lowest serum hsCRP quartile, those in the highest quartile showed a significant lower HGS, with a linear decrease of HGS across increasing serum hsCRP quartiles. Men with low muscle strength had 74.2% higher serum hsCRP than those without, and each standard deviation increment in serum hsCRP was associated with a multivariate-adjusted odds ratio of 1.35 for the risk of low muscle strength in men. However, these associations were not statistically significant in women. These findings provide clinical evidence that chronic subclinical low-grade inflammation may contribute to the deterioration of muscle strength seen with aging, especially in men.
AB - Despite the potential detrimental effects of systemic inflammation on muscle mass, which is mainly observed in patients with pathologic diseases, its role in muscle strength, especially in a healthy general population reflecting subclinical low-grade inflammation, is unclear. This is a nationally representative population-based, cross-sectional study from the Korea National Health and Nutrition Examination Survey, which enrolled 1,036 men aged ≥50 years and 1,080 postmenopausal women. After adjustment for confounders, serum highsensitivity C-reactive protein (hsCRP) level was inversely associated with hand grip strength (HGS) in men. Consistently, compared with men in the lowest serum hsCRP quartile, those in the highest quartile showed a significant lower HGS, with a linear decrease of HGS across increasing serum hsCRP quartiles. Men with low muscle strength had 74.2% higher serum hsCRP than those without, and each standard deviation increment in serum hsCRP was associated with a multivariate-adjusted odds ratio of 1.35 for the risk of low muscle strength in men. However, these associations were not statistically significant in women. These findings provide clinical evidence that chronic subclinical low-grade inflammation may contribute to the deterioration of muscle strength seen with aging, especially in men.
KW - Hand grip strength
KW - High sensitivity C-reactive protein
KW - Inflammation
KW - Muscle strength
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85052605039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052605039&partnerID=8YFLogxK
U2 - 10.18632/aging.101529
DO - 10.18632/aging.101529
M3 - Article
C2 - 30115813
AN - SCOPUS:85052605039
VL - 10
SP - 2051
EP - 2061
JO - Aging
JF - Aging
SN - 0002-0966
IS - 8
ER -