TY - JOUR
T1 - Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline
AU - Appel, James B.
AU - Callahan, Patrick M.
N1 - Funding Information:
This research was supported by USPHS Research Grant RO1 DA02543, from the National Institute on Drug Abuse; a preliminary report of the data was presented at the Society for Neuroscience Annual Meeting (Satellite Session of the Society for the Stimulus Properties of Drugs) New Orleans, 1987.
PY - 1989/1/2
Y1 - 1989/1/2
N2 - In order to further evaluate the extent to which particular 5-HT receptor subtypes (5-HT1, 5-HT2) might be involved in the behavioral effects of hallucinogenic drugs, rats were trained to discriminate mescaline (10 mg/kg i.p.) from saline and were given substitution (generalization) and combination (antagonism) tests with putatively selective serotonergic and related neuroactive compounds. The mescaline cue generalized to relatively high doses of the 5-HT2 agonists, 2,5-dimethoxy-4-methylamphetamine (DOM), LSD and psilocybin; the extent of generalization to 5-HT1 agonists (8-hydroxy-2-[diethylamino]tetralin (8-OHDPAT), RU-24969 and 8-hydroxy-2-[di-n-propylamino]tetralin (TFMPP) was unclear. Combinations of the training drug and sufficiently high doses of 5-HT2 antagonists (ketanserin, LY-53857, pirenperone) were followed by saline-lever responding; less selective central 5-HT (metergoline), and DA (SCH-23390, haloperidol) antagonists, did not block the mescaline cue. These data suggest that 5-HT2 receptors are involved in the stimulus properties of mescaline.
AB - In order to further evaluate the extent to which particular 5-HT receptor subtypes (5-HT1, 5-HT2) might be involved in the behavioral effects of hallucinogenic drugs, rats were trained to discriminate mescaline (10 mg/kg i.p.) from saline and were given substitution (generalization) and combination (antagonism) tests with putatively selective serotonergic and related neuroactive compounds. The mescaline cue generalized to relatively high doses of the 5-HT2 agonists, 2,5-dimethoxy-4-methylamphetamine (DOM), LSD and psilocybin; the extent of generalization to 5-HT1 agonists (8-hydroxy-2-[diethylamino]tetralin (8-OHDPAT), RU-24969 and 8-hydroxy-2-[di-n-propylamino]tetralin (TFMPP) was unclear. Combinations of the training drug and sufficiently high doses of 5-HT2 antagonists (ketanserin, LY-53857, pirenperone) were followed by saline-lever responding; less selective central 5-HT (metergoline), and DA (SCH-23390, haloperidol) antagonists, did not block the mescaline cue. These data suggest that 5-HT2 receptors are involved in the stimulus properties of mescaline.
KW - 5-HT receptors
KW - 5-HT receptors
KW - 5-HT receptors
KW - Drug discrimination
KW - Hallucinogens
KW - Mescaline
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U2 - 10.1016/0014-2999(89)90041-1
DO - 10.1016/0014-2999(89)90041-1
M3 - Article
C2 - 2707301
AN - SCOPUS:0024578313
SN - 0014-2999
VL - 159
SP - 41
EP - 46
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -