Abstract
The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-178 |
| Number of pages | 6 |
| Journal | Neuroscience and Behavioral Physiology |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
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Keywords
- Brain blood flow
- Extracellular superoxide dismutase
- Nitric oxide
- Superoxide anions
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Involvement of extracellular superoxide dismutase in regulating brain blood flow. / Demchenko, I. T.; Gutsaeva, Diana Raisovna; Moskvin, A. N.; Zhilyaev, S. Yu.
In: Neuroscience and Behavioral Physiology, Vol. 40, No. 2, 01.01.2010, p. 173-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of extracellular superoxide dismutase in regulating brain blood flow
AU - Demchenko, I. T.
AU - Gutsaeva, Diana Raisovna
AU - Moskvin, A. N.
AU - Zhilyaev, S. Yu
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.
AB - The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.
KW - Brain blood flow
KW - Extracellular superoxide dismutase
KW - Nitric oxide
KW - Superoxide anions
UR - http://www.scopus.com/inward/record.url?scp=77949273851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949273851&partnerID=8YFLogxK
U2 - 10.1007/s11055-009-9240-5
DO - 10.1007/s11055-009-9240-5
M3 - Article
C2 - 20033309
AN - SCOPUS:77949273851
VL - 40
SP - 173
EP - 178
JO - Neuroscience and Behavioral Physiology
JF - Neuroscience and Behavioral Physiology
SN - 0097-0549
IS - 2
ER -