Involvement of extracellular superoxide dismutase in regulating brain blood flow

I. T. Demchenko; D. R. Gutsaeva; A. N. Moskvin; S. Yu Zhilyaev

doi:10.1007/s11055-009-9240-5

Involvement of extracellular superoxide dismutase in regulating brain blood flow

I. T. Demchenko, D. R. Gutsaeva, A. N. Moskvin, S. Yu Zhilyaev

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O ₂ ^- ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O ₂ ^- levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O₂ and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Neuroscience and Behavioral Physiology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1007/s11055-009-9240-5
State	Published - 2010
Externally published	Yes

Keywords

Brain blood flow
Extracellular superoxide dismutase
Nitric oxide
Superoxide anions

ASJC Scopus subject areas

Neuroscience(all)

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title = "Involvement of extracellular superoxide dismutase in regulating brain blood flow",

abstract = "The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.",

keywords = "Brain blood flow, Extracellular superoxide dismutase, Nitric oxide, Superoxide anions",

author = "Demchenko, {I. T.} and Gutsaeva, {D. R.} and Moskvin, {A. N.} and Zhilyaev, {S. Yu}",

note = "Funding Information: The authors would like to thank Dr Ines Batinic-Haberle (Duke University Medical Center, USA) for providing the SOD mimetic MnTE-2-PyP5+ used here. This study was supported by the Russian Foundation for Basic Research (Grants Nos. 06-04-49697 and 07-04-01121).",

year = "2010",

doi = "10.1007/s11055-009-9240-5",

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AU - Gutsaeva, D. R.

AU - Moskvin, A. N.

AU - Zhilyaev, S. Yu

N1 - Funding Information: The authors would like to thank Dr Ines Batinic-Haberle (Duke University Medical Center, USA) for providing the SOD mimetic MnTE-2-PyP5+ used here. This study was supported by the Russian Foundation for Basic Research (Grants Nos. 06-04-49697 and 07-04-01121).

PY - 2010

Y1 - 2010

N2 - The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.

AB - The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.

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KW - Superoxide anions

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Involvement of extracellular superoxide dismutase in regulating brain blood flow

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