Involvement of extracellular superoxide dismutase in regulating brain blood flow

I. T. Demchenko, D. R. Gutsaeva, A. N. Moskvin, S. Yu Zhilyaev

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O 2 - ) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O 2 - levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalNeuroscience and Behavioral Physiology
Volume40
Issue number2
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Brain blood flow
  • Extracellular superoxide dismutase
  • Nitric oxide
  • Superoxide anions

ASJC Scopus subject areas

  • Neuroscience(all)

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