Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry

Iryna O. Lebedyeva, Alexander A. Oliferenko, Polina V. Oliferenko, Robert A. Hromas, John K. Neubert, Robert M. Caudle, Jay Wickersham, William L. Castleman, Gary I. Altschuler, David A. Ostrov, C. Dennis Hall, Alan R. Katritzky

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1 Scopus citations

Abstract

Lidocaine is the most widely utilized intraoral injected dental anesthetic, used for more than 500 million dental injections per year. Local anesthesia is essential for pain-free dentistry, yet intraoral injections are often considered painful and a source of anxiety for many patients. Any new anesthetics that will reduce the stress and anxiety of dental injection are expected to be beneficial. A novel chemical approach to taste modulation is proposed, in which the lidocaine cation is coupled with anionic sweeteners such as saccarinate and acesulfamate. The ionic conjugates synthesized using anion exchange techniques, were much less bitter, demonstrated a high local anesthetic potential in animal studies, and were as safe as the original hydrochloride. Based on the currently robust market for lidocaine it is expected that the resulting anesthetics will be in high demand in clinical practices worldwide.

Original languageEnglish (US)
Pages (from-to)8492-8498
Number of pages7
JournalJournal of Materials Chemistry B
Volume3
Issue number43
DOIs
StatePublished - Sep 23 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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    Lebedyeva, I. O., Oliferenko, A. A., Oliferenko, P. V., Hromas, R. A., Neubert, J. K., Caudle, R. M., Wickersham, J., Castleman, W. L., Altschuler, G. I., Ostrov, D. A., Hall, C. D., & Katritzky, A. R. (2015). Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry. Journal of Materials Chemistry B, 3(43), 8492-8498. https://doi.org/10.1039/c5tb00674k