Abstract
Lidocaine is the most widely utilized intraoral injected dental anesthetic, used for more than 500 million dental injections per year. Local anesthesia is essential for pain-free dentistry, yet intraoral injections are often considered painful and a source of anxiety for many patients. Any new anesthetics that will reduce the stress and anxiety of dental injection are expected to be beneficial. A novel chemical approach to taste modulation is proposed, in which the lidocaine cation is coupled with anionic sweeteners such as saccarinate and acesulfamate. The ionic conjugates synthesized using anion exchange techniques, were much less bitter, demonstrated a high local anesthetic potential in animal studies, and were as safe as the original hydrochloride. Based on the currently robust market for lidocaine it is expected that the resulting anesthetics will be in high demand in clinical practices worldwide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8492-8498 |
| Number of pages | 7 |
| Journal | Journal of Materials Chemistry B |
| Volume | 3 |
| Issue number | 43 |
| DOIs | |
| State | Published - Sep 23 2015 |
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ASJC Scopus subject areas
- Chemistry(all)
- Biomedical Engineering
- Materials Science(all)
Cite this
Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry. / Lebedyeva, Iryna O.; Oliferenko, Alexander A.; Oliferenko, Polina V.; Hromas, Robert A.; Neubert, John K.; Caudle, Robert M.; Wickersham, Jay; Castleman, William L.; Altschuler, Gary I.; Ostrov, David A.; Hall, C. Dennis; Katritzky, Alan R.
In: Journal of Materials Chemistry B, Vol. 3, No. 43, 23.09.2015, p. 8492-8498.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry
AU - Lebedyeva, Iryna O.
AU - Oliferenko, Alexander A.
AU - Oliferenko, Polina V.
AU - Hromas, Robert A.
AU - Neubert, John K.
AU - Caudle, Robert M.
AU - Wickersham, Jay
AU - Castleman, William L.
AU - Altschuler, Gary I.
AU - Ostrov, David A.
AU - Hall, C. Dennis
AU - Katritzky, Alan R.
PY - 2015/9/23
Y1 - 2015/9/23
N2 - Lidocaine is the most widely utilized intraoral injected dental anesthetic, used for more than 500 million dental injections per year. Local anesthesia is essential for pain-free dentistry, yet intraoral injections are often considered painful and a source of anxiety for many patients. Any new anesthetics that will reduce the stress and anxiety of dental injection are expected to be beneficial. A novel chemical approach to taste modulation is proposed, in which the lidocaine cation is coupled with anionic sweeteners such as saccarinate and acesulfamate. The ionic conjugates synthesized using anion exchange techniques, were much less bitter, demonstrated a high local anesthetic potential in animal studies, and were as safe as the original hydrochloride. Based on the currently robust market for lidocaine it is expected that the resulting anesthetics will be in high demand in clinical practices worldwide.
AB - Lidocaine is the most widely utilized intraoral injected dental anesthetic, used for more than 500 million dental injections per year. Local anesthesia is essential for pain-free dentistry, yet intraoral injections are often considered painful and a source of anxiety for many patients. Any new anesthetics that will reduce the stress and anxiety of dental injection are expected to be beneficial. A novel chemical approach to taste modulation is proposed, in which the lidocaine cation is coupled with anionic sweeteners such as saccarinate and acesulfamate. The ionic conjugates synthesized using anion exchange techniques, were much less bitter, demonstrated a high local anesthetic potential in animal studies, and were as safe as the original hydrochloride. Based on the currently robust market for lidocaine it is expected that the resulting anesthetics will be in high demand in clinical practices worldwide.
UR - http://www.scopus.com/inward/record.url?scp=84946126225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946126225&partnerID=8YFLogxK
U2 - 10.1039/c5tb00674k
DO - 10.1039/c5tb00674k
M3 - Article
VL - 3
SP - 8492
EP - 8498
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-7518
IS - 43
ER -