Iontophoresis of vidarabine monophosphate for herpes orolabialis

Louis P. Gangarosa, James M. Hill, Barry L. Thompson, Carol Leggett, J. Peter Kissing

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV), and nine received NaCl. Ara-AMP-treated lesions yielded lower titers of virus after 24 hr compared with lesions treated with NaCl or ACV (P < .05) and time to dry crust (P < .05) compared with the other two agents. There was a trend toward decreased healing time after ara-AMP treatment.

Original languageEnglish (US)
Pages (from-to)930-934
Number of pages5
JournalJournal of Infectious Diseases
Volume154
Issue number6
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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