Iq motif-containing gtpase-activating protein 1 is essential for the optimal maintenance of lung ilc2s

Shunichi Tayama, Yuko Okuyama, Hai The Phung, Atsuko Asao, Shuhei Kobayashi, Tomomi Musha, Tomoaki MacHiyama, Tsuyoshi Sakurai, Chengming Zhang, Masuko Ushio-Fukai, Takeshi Kawabe, Takanori So, Naoto Ishii

Research output: Contribution to journalArticle

Abstract

Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory disease. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffold protein that is involved in multiple cellular functions such as cell survival and trafficking. While the roles for IQGAP1 in T and B lymphocytes have been uncovered, the physiological significance of IQGAP1 in innate lymphocytes remains to be elucidated. In the current study, we demonstrate that using bone marrow chimeras, the deficiency of IQGAP1 caused an impaired survival of lung ILC2s in a cell-intrinsic manner and that Iqgap1-/-mice displayed decreased accumulation of ILC2s after administration of papain and thereby reduced the pathology of the disease. Moreover, Iqgap1-/-ILC2s showed a significantly enhanced apoptosis as compared to wild-type ILC2s under both steady-state and inflammatory conditions. Together these results identify for the first time that IQGAP1 is essential for homeostasis of ILC2s in the lung.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalInternational Immunology
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2020

Keywords

  • Allergic lung inflammation
  • Cell apoptosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Tayama, S., Okuyama, Y., Phung, H. T., Asao, A., Kobayashi, S., Musha, T., MacHiyama, T., Sakurai, T., Zhang, C., Ushio-Fukai, M., Kawabe, T., So, T., & Ishii, N. (2020). Iq motif-containing gtpase-activating protein 1 is essential for the optimal maintenance of lung ilc2s. International Immunology, 32(4), 233-241. https://doi.org/10.1093/intimm/dxaa077