Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females

Norman K. Pollock, Emma M. Laing, Clifton A. Baile, Mark W Hamrick, Daniel B. Hall, Richard D. Lewis

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal. Objectives: Relations of percentage body fat (BF) and bone strength indexes were assessed in late adolescent females, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and bone length]. Bone measurements in the normal- and high-fat groups were also compared. Design: Late adolescent females (n = 115; aged 18.2 ± 0.4 y) participated in this cross-sectional study. Fat-free soft tissue mass, fat mass, and percentage BF were measured with the use of dualenergy X-ray absorptiometry. Tibial and radial peripheral quantitative computed tomography measurements were taken at the 4% (trabecular bone), 20% (cortical bone), and 66% (for measurement of MCSA) sites from the distal metaphyses. Results: Percentage BF was inversely related to radial cortical bone area, total bone cross-sectional area (CSA), cortical bone mineral content (BMC), periosteal circumference, and strength-strain index (SSI) (20% site; all P < 0.05). After control for MCSA and limb length, negative relations remained between percentage BF and radial measurements and were also observed at the tibia (20% site). Unadjusted bone measures were not different between groups. After control for MCSA, the high- compared with the normal-fat group had lower bone measures at the 20% site (cortical bone area and cortical BMC at the tibia, total bone CSA at the radius, and SSI at both the tibia and radius; P < 0.05 for all). Conclusion: Excess weight in the form of fat mass does not provide additional benefits, and may potentially be negative, for adolescent bone.

Original languageEnglish (US)
Pages (from-to)1530-1538
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume86
Issue number5
StatePublished - Nov 1 2007

Fingerprint

bone strength
Adiposity
adiposity
computed tomography
Tomography
bones
Bone and Bones
Fats
Adipose Tissue
Muscles
Tibia
body fat
muscles
lipids
tibia
Bone Density
radius (bone)
mineral content
Photon Absorptiometry
Skeleton

Keywords

  • Body composition
  • Bone strength
  • Late adolescent
  • Obesity
  • Peripheral quantitative computed tomography
  • PQCT

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females. / Pollock, Norman K.; Laing, Emma M.; Baile, Clifton A.; Hamrick, Mark W; Hall, Daniel B.; Lewis, Richard D.

In: American Journal of Clinical Nutrition, Vol. 86, No. 5, 01.11.2007, p. 1530-1538.

Research output: Contribution to journalArticle

@article{2a39068875a844ccbaf3499167033357,
title = "Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females",
abstract = "Background: Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal. Objectives: Relations of percentage body fat (BF) and bone strength indexes were assessed in late adolescent females, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and bone length]. Bone measurements in the normal- and high-fat groups were also compared. Design: Late adolescent females (n = 115; aged 18.2 ± 0.4 y) participated in this cross-sectional study. Fat-free soft tissue mass, fat mass, and percentage BF were measured with the use of dualenergy X-ray absorptiometry. Tibial and radial peripheral quantitative computed tomography measurements were taken at the 4{\%} (trabecular bone), 20{\%} (cortical bone), and 66{\%} (for measurement of MCSA) sites from the distal metaphyses. Results: Percentage BF was inversely related to radial cortical bone area, total bone cross-sectional area (CSA), cortical bone mineral content (BMC), periosteal circumference, and strength-strain index (SSI) (20{\%} site; all P < 0.05). After control for MCSA and limb length, negative relations remained between percentage BF and radial measurements and were also observed at the tibia (20{\%} site). Unadjusted bone measures were not different between groups. After control for MCSA, the high- compared with the normal-fat group had lower bone measures at the 20{\%} site (cortical bone area and cortical BMC at the tibia, total bone CSA at the radius, and SSI at both the tibia and radius; P < 0.05 for all). Conclusion: Excess weight in the form of fat mass does not provide additional benefits, and may potentially be negative, for adolescent bone.",
keywords = "Body composition, Bone strength, Late adolescent, Obesity, Peripheral quantitative computed tomography, PQCT",
author = "Pollock, {Norman K.} and Laing, {Emma M.} and Baile, {Clifton A.} and Hamrick, {Mark W} and Hall, {Daniel B.} and Lewis, {Richard D.}",
year = "2007",
month = "11",
day = "1",
language = "English (US)",
volume = "86",
pages = "1530--1538",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females

AU - Pollock, Norman K.

AU - Laing, Emma M.

AU - Baile, Clifton A.

AU - Hamrick, Mark W

AU - Hall, Daniel B.

AU - Lewis, Richard D.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Background: Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal. Objectives: Relations of percentage body fat (BF) and bone strength indexes were assessed in late adolescent females, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and bone length]. Bone measurements in the normal- and high-fat groups were also compared. Design: Late adolescent females (n = 115; aged 18.2 ± 0.4 y) participated in this cross-sectional study. Fat-free soft tissue mass, fat mass, and percentage BF were measured with the use of dualenergy X-ray absorptiometry. Tibial and radial peripheral quantitative computed tomography measurements were taken at the 4% (trabecular bone), 20% (cortical bone), and 66% (for measurement of MCSA) sites from the distal metaphyses. Results: Percentage BF was inversely related to radial cortical bone area, total bone cross-sectional area (CSA), cortical bone mineral content (BMC), periosteal circumference, and strength-strain index (SSI) (20% site; all P < 0.05). After control for MCSA and limb length, negative relations remained between percentage BF and radial measurements and were also observed at the tibia (20% site). Unadjusted bone measures were not different between groups. After control for MCSA, the high- compared with the normal-fat group had lower bone measures at the 20% site (cortical bone area and cortical BMC at the tibia, total bone CSA at the radius, and SSI at both the tibia and radius; P < 0.05 for all). Conclusion: Excess weight in the form of fat mass does not provide additional benefits, and may potentially be negative, for adolescent bone.

AB - Background: Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal. Objectives: Relations of percentage body fat (BF) and bone strength indexes were assessed in late adolescent females, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and bone length]. Bone measurements in the normal- and high-fat groups were also compared. Design: Late adolescent females (n = 115; aged 18.2 ± 0.4 y) participated in this cross-sectional study. Fat-free soft tissue mass, fat mass, and percentage BF were measured with the use of dualenergy X-ray absorptiometry. Tibial and radial peripheral quantitative computed tomography measurements were taken at the 4% (trabecular bone), 20% (cortical bone), and 66% (for measurement of MCSA) sites from the distal metaphyses. Results: Percentage BF was inversely related to radial cortical bone area, total bone cross-sectional area (CSA), cortical bone mineral content (BMC), periosteal circumference, and strength-strain index (SSI) (20% site; all P < 0.05). After control for MCSA and limb length, negative relations remained between percentage BF and radial measurements and were also observed at the tibia (20% site). Unadjusted bone measures were not different between groups. After control for MCSA, the high- compared with the normal-fat group had lower bone measures at the 20% site (cortical bone area and cortical BMC at the tibia, total bone CSA at the radius, and SSI at both the tibia and radius; P < 0.05 for all). Conclusion: Excess weight in the form of fat mass does not provide additional benefits, and may potentially be negative, for adolescent bone.

KW - Body composition

KW - Bone strength

KW - Late adolescent

KW - Obesity

KW - Peripheral quantitative computed tomography

KW - PQCT

UR - http://www.scopus.com/inward/record.url?scp=36249021055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36249021055&partnerID=8YFLogxK

M3 - Article

C2 - 17991669

AN - SCOPUS:36249021055

VL - 86

SP - 1530

EP - 1538

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -