Is coffee a colonic stimulant?

Satish Sanku Chander Rao, Kimberly Welcher, Bridget Zimmerman, Phyllis Stumbo

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background. It is unclear if ingestion of coffee affects colonic function and if this effect is due to its caffeine content. We investigated the effects of coffee on colonic motor activity in healthy humans. Methods. We performed ambulatory colonic manometry by placing a six-sensor solid-state probe up to the midtransverse colon in 12 healthy subjects. The following day, over a 10 h period, subjects received four stimuli: 240 ml of three drinks at 45°C in random order: black Colombian coffee (150 mg caffeine), decaffeinated coffee or water and 1000 kcal meal. We analyzed the effects of each stimulant on colonic motor responses. Results. Caffeinated coffee, decaffeinated coffee and meal induced more activity in the colon with a greater area under the curve of pressure waves (P < 0.01) and a greater number of propagated contractions (P < 0.05) when compared with water. Caffeinated coffee, decaffeinated coffee and meal induced greater (P < 0.05) motor activity in the transverse/descending colon when compared with the rectosigmoid colon. The effects of decaffeinated coffee on colonic motility were not significantly different from those of water or caffeinated coffee and were lower (P < 0.05) than that of a meal. Conclusion. Caffeinated coffee stimulates colonic motor activity. Its magnitude is similar to a meal, 60% stronger than water and 23% stronger than decaffeinated coffee.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Coffee
Meals
Colon
Motor Activity
Water
Caffeine
Descending Colon
Transverse Colon
Manometry
Area Under Curve
Healthy Volunteers
Eating

Keywords

  • Coffee
  • Colonic stimulant

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Is coffee a colonic stimulant? / Rao, Satish Sanku Chander; Welcher, Kimberly; Zimmerman, Bridget; Stumbo, Phyllis.

In: European Journal of Gastroenterology and Hepatology, Vol. 10, No. 2, 01.01.1998, p. 113-118.

Research output: Contribution to journalArticle

Rao, Satish Sanku Chander ; Welcher, Kimberly ; Zimmerman, Bridget ; Stumbo, Phyllis. / Is coffee a colonic stimulant?. In: European Journal of Gastroenterology and Hepatology. 1998 ; Vol. 10, No. 2. pp. 113-118.
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