Is idiopathic pulmonary fibrosis an environmental disease?

Varsha S. Taskar, David B. Coultas

Research output: Contribution to journalReview article

187 Citations (Scopus)

Abstract

Several sources of evidence, including investigations of pathogenesis and observational studies, support the hypothesis that environmental agents may have an etiologic role in idiopathic pulmonary fibrosis (IPF). Since 1990, six case-control studies have been conducted in three countries and have consistently demonstrated increased risk of IPF with exposures to a number of environmental and occupational agents. In a meta-analysis of these studies, six exposures were significantly associated with IPF (summary odds ratios [95% confidence intervals]), including ever smoking (1.58 [1.27-1.97]), agriculture/farming (1.65 [1.20-2.26]), livestock (2.17 [1.28-3.68]), wood dust (1.94 [1.34-2.81]), metal dust (2.44 [1.74-3.40]), and stone/sand (1.97 [1.09-3.55]). Although there are a number of limitations of the case-control design and these results alone do not establish a causal link, an assessment of all of the available evidence strongly suggests that IPF may be a heterogeneous disorder caused by a number of environmental and occupational exposures.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalProceedings of the American Thoracic Society
Volume3
Issue number4
DOIs
StatePublished - Jun 1 2006

Fingerprint

Idiopathic Pulmonary Fibrosis
Agriculture
Dust
Environmental Exposure
Livestock
Occupational Exposure
Observational Studies
Meta-Analysis
Case-Control Studies
Smoking
Metals
Odds Ratio
Confidence Intervals

Keywords

  • Interstitial lung diseases
  • Occupation
  • Risk
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Is idiopathic pulmonary fibrosis an environmental disease? / Taskar, Varsha S.; Coultas, David B.

In: Proceedings of the American Thoracic Society, Vol. 3, No. 4, 01.06.2006, p. 293-298.

Research output: Contribution to journalReview article

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