Is insulin resistance linked to hypertension?

Michael W. Brands, John E. Hall, Henry L. Keen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. The volume of work reporting insulin resistance in multiple forms of chronic hypertension has generated tremendous interest in whether this abnormality is an important factor in causing hypertension. Insulin resistance, however, is an imprecise term used interchangeably to describe widely disparate types of impairment in insulin action throughput the body and the type of insulin resistance has major ramifications regarding its potential for inducing long-term increases in blood pressure (BP). 2. Hepatic insulin resistance (impaired insulin-mediated suppression of hepatic glucose output) is the primary cause of fasting hyperinsulinaemia and is a cardinal feature of obesity hypertension. Evidence from chronic insulin infusion studies in rats suggests hyperinsulinaemia can increase BP under some conditions; however, conflicting evidence in humans and dogs leaves in question whether hyperinsulinaemia is a factor in hypertension induced by obesity. 3. Peripheral insulin resistance (impaired insulin-mediated glucose uptake, primarily of an acute glucose load in skeletal muscle) also present in obesity hypertension, but now reported in lean essential hypertension as well, is linked most notably to impaired insulin-mediated skeletal muscle vasodilation. This derangement has also been proposed as a mechanism through which insulin resistance can cause hypertension. 4. The present review will discuss the lack of experimental or theoretical support for that hypothesis and will suggest that a direct link between insulin resistance and BP control may not be the best way to envision a role for insulin resistance in cardiovascular morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)70-76
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Insulin Resistance
Hypertension
Insulin
Hyperinsulinism
Obesity
Blood Pressure
Glucose
Skeletal Muscle
Somatotypes
Liver
Vasodilation
Vascular Resistance
Fasting
Dogs
Morbidity
Mortality

Keywords

  • Blood flow
  • Blood pressure
  • Hypertension
  • Insulin
  • Insulin resistance
  • Obesity
  • Pressure natriuresis
  • Sodium excretion
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Is insulin resistance linked to hypertension? / Brands, Michael W.; Hall, John E.; Keen, Henry L.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 25, No. 1, 01.01.1998, p. 70-76.

Research output: Contribution to journalArticle

@article{24fe90ea079848fbad7e5fa57b83c0cf,
title = "Is insulin resistance linked to hypertension?",
abstract = "1. The volume of work reporting insulin resistance in multiple forms of chronic hypertension has generated tremendous interest in whether this abnormality is an important factor in causing hypertension. Insulin resistance, however, is an imprecise term used interchangeably to describe widely disparate types of impairment in insulin action throughput the body and the type of insulin resistance has major ramifications regarding its potential for inducing long-term increases in blood pressure (BP). 2. Hepatic insulin resistance (impaired insulin-mediated suppression of hepatic glucose output) is the primary cause of fasting hyperinsulinaemia and is a cardinal feature of obesity hypertension. Evidence from chronic insulin infusion studies in rats suggests hyperinsulinaemia can increase BP under some conditions; however, conflicting evidence in humans and dogs leaves in question whether hyperinsulinaemia is a factor in hypertension induced by obesity. 3. Peripheral insulin resistance (impaired insulin-mediated glucose uptake, primarily of an acute glucose load in skeletal muscle) also present in obesity hypertension, but now reported in lean essential hypertension as well, is linked most notably to impaired insulin-mediated skeletal muscle vasodilation. This derangement has also been proposed as a mechanism through which insulin resistance can cause hypertension. 4. The present review will discuss the lack of experimental or theoretical support for that hypothesis and will suggest that a direct link between insulin resistance and BP control may not be the best way to envision a role for insulin resistance in cardiovascular morbidity and mortality.",
keywords = "Blood flow, Blood pressure, Hypertension, Insulin, Insulin resistance, Obesity, Pressure natriuresis, Sodium excretion, Vasoconstriction",
author = "Brands, {Michael W.} and Hall, {John E.} and Keen, {Henry L.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1111/j.1440-1681.1998.tb02148.x",
language = "English (US)",
volume = "25",
pages = "70--76",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Is insulin resistance linked to hypertension?

AU - Brands, Michael W.

AU - Hall, John E.

AU - Keen, Henry L.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - 1. The volume of work reporting insulin resistance in multiple forms of chronic hypertension has generated tremendous interest in whether this abnormality is an important factor in causing hypertension. Insulin resistance, however, is an imprecise term used interchangeably to describe widely disparate types of impairment in insulin action throughput the body and the type of insulin resistance has major ramifications regarding its potential for inducing long-term increases in blood pressure (BP). 2. Hepatic insulin resistance (impaired insulin-mediated suppression of hepatic glucose output) is the primary cause of fasting hyperinsulinaemia and is a cardinal feature of obesity hypertension. Evidence from chronic insulin infusion studies in rats suggests hyperinsulinaemia can increase BP under some conditions; however, conflicting evidence in humans and dogs leaves in question whether hyperinsulinaemia is a factor in hypertension induced by obesity. 3. Peripheral insulin resistance (impaired insulin-mediated glucose uptake, primarily of an acute glucose load in skeletal muscle) also present in obesity hypertension, but now reported in lean essential hypertension as well, is linked most notably to impaired insulin-mediated skeletal muscle vasodilation. This derangement has also been proposed as a mechanism through which insulin resistance can cause hypertension. 4. The present review will discuss the lack of experimental or theoretical support for that hypothesis and will suggest that a direct link between insulin resistance and BP control may not be the best way to envision a role for insulin resistance in cardiovascular morbidity and mortality.

AB - 1. The volume of work reporting insulin resistance in multiple forms of chronic hypertension has generated tremendous interest in whether this abnormality is an important factor in causing hypertension. Insulin resistance, however, is an imprecise term used interchangeably to describe widely disparate types of impairment in insulin action throughput the body and the type of insulin resistance has major ramifications regarding its potential for inducing long-term increases in blood pressure (BP). 2. Hepatic insulin resistance (impaired insulin-mediated suppression of hepatic glucose output) is the primary cause of fasting hyperinsulinaemia and is a cardinal feature of obesity hypertension. Evidence from chronic insulin infusion studies in rats suggests hyperinsulinaemia can increase BP under some conditions; however, conflicting evidence in humans and dogs leaves in question whether hyperinsulinaemia is a factor in hypertension induced by obesity. 3. Peripheral insulin resistance (impaired insulin-mediated glucose uptake, primarily of an acute glucose load in skeletal muscle) also present in obesity hypertension, but now reported in lean essential hypertension as well, is linked most notably to impaired insulin-mediated skeletal muscle vasodilation. This derangement has also been proposed as a mechanism through which insulin resistance can cause hypertension. 4. The present review will discuss the lack of experimental or theoretical support for that hypothesis and will suggest that a direct link between insulin resistance and BP control may not be the best way to envision a role for insulin resistance in cardiovascular morbidity and mortality.

KW - Blood flow

KW - Blood pressure

KW - Hypertension

KW - Insulin

KW - Insulin resistance

KW - Obesity

KW - Pressure natriuresis

KW - Sodium excretion

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=0031931748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031931748&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.1998.tb02148.x

DO - 10.1111/j.1440-1681.1998.tb02148.x

M3 - Article

C2 - 9493563

AN - SCOPUS:0031931748

VL - 25

SP - 70

EP - 76

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 1

ER -