Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

Eugene Kim, Ming Jiang, Huachao Huang, Yongchun Zhang, Natalie Tjota, Xia Gao, Jacques Robert, Nikesha Gilmore, Lin Gan, Jianwen Que

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The disease mechanism of the birth defect esophageal atresia with or without trachea-esophageal fistula remains largely unknown. Kim et al. used Xenopus and mouse genetic models to show that an Isl1-Nkx2.1 axis regulates a midline epithelial progenitor cell population that orchestrates trachea-esophageal separation.

Original languageEnglish (US)
Pages (from-to)675-683.e4
JournalDevelopmental Cell
Volume51
Issue number6
DOIs
StatePublished - Dec 16 2019
Externally publishedYes

Keywords

  • EA/TEF
  • Isl1
  • Nkx2.1
  • Sox2
  • esophageal atresia
  • foregut separation
  • lobation
  • lung development

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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