Janus Nanoparticles for Improved Dentin Bonding

Bing Han, Wendi Xia, Kaining Liu, Fucong Tian, Ying Chen, Xiaoyan Wang, Fuxin Liang, Zhenzhong Yang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The amphiphilic monomer 2-hydroxyethyl methacrylate (HEMA) is widely used in dental adhesives as a priming component, especially for dentin bonding. It behaves as a compatibilizer between hydrophilic and hydrophobic components and stabilizes the multicomponent adhesive system. However, there are several drawbacks associated with using HEMA, such as water retention within the adhesive layer, hydrolysis in oral environments, and cytotoxicity. These drawbacks lead to the failure of tooth restoration and represent a heavy medical burden. Thus, it is imperative to find a new compatibilizer to substitute for HEMA. Because of their superior compatibilization capabilities as functional solid surfactants, amphiphilic Janus particles are chosen as candidates for an alternative to HEMA in dental adhesives. Reactive amphiphilic Janus nanoparticles are synthesized by selectively etching and modifying at the interface of a Pickering emulsion. This approach could be extended to the synthesis of a series of other Janus nanoparticles. The Janus nanoparticles were verified to be better for the reduction of the phase separation and stabilization of dentin adhesives than HEMA. It is also demonstrated that these reactive Janus nanoparticles can strongly enhance the dentin bonding interface without cytotoxicity. It is clearly illustrated by this study that Janus nanoparticles may be promising materials to substitute for HEMA in dental adhesives.

Original languageEnglish (US)
Pages (from-to)8519-8526
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number10
StatePublished - Mar 14 2018


  • HEMA
  • Janus nanoparticles
  • adhesive
  • amphipathy
  • dentin bonding

ASJC Scopus subject areas

  • Materials Science(all)


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