Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity

Albert M. Levin, Alexandra R. Sitarik, Suzanne L. Havstad, Kei E. Fujimura, Ganesa Wegienka, Andrea E. Cassidy-Bushrow, Haejin Kim, Edward M. Zoratti, Nicholas W. Lukacs, Homer A. Boushey, Dennis Randall Ownby, Susan V. Lynch, Christine C. Johnson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The joint impact of pregnancy, environmental, and sociocultural exposures on early life gut microbiome is not yet well-characterized, especially in racially and socioeconomically diverse populations. Gut microbiota of 298 children from a Detroit-based birth cohort were profiled using 16S rRNA sequencing: 130 neonates (median age = 1.2 months) and 168 infants (median age = 6.6 months). Multiple factors were associated with neonatal gut microbiome composition in both single- and multi-factor models, with independent contributions of maternal race-ethnicity, breastfeeding, mode of delivery, marital status, exposure to environmental tobacco smoke, and indoor pets. These findings were consistent in the infants, and networks demonstrating the shared impact of factors on gut microbial composition also showed notable topological similarity between neonates and infants. Further, latent groups defined by these factors explained additional variation, highlighting the importance of combinatorial effects. Our findings also have implications for studies investigating the impact of the early life gut microbiota on disease.

Original languageEnglish (US)
Article number31775
JournalScientific Reports
Volume6
DOIs
StatePublished - Aug 25 2016

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Pregnancy
Environmental Exposure
proctolin
Newborn Infant
Pets
Marital Status
Breast Feeding
Smoke
Tobacco
Joints
Mothers
Parturition
Gastrointestinal Microbiome
Population

ASJC Scopus subject areas

  • General

Cite this

Levin, A. M., Sitarik, A. R., Havstad, S. L., Fujimura, K. E., Wegienka, G., Cassidy-Bushrow, A. E., ... Johnson, C. C. (2016). Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity. Scientific Reports, 6, [31775]. https://doi.org/10.1038/srep31775

Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity. / Levin, Albert M.; Sitarik, Alexandra R.; Havstad, Suzanne L.; Fujimura, Kei E.; Wegienka, Ganesa; Cassidy-Bushrow, Andrea E.; Kim, Haejin; Zoratti, Edward M.; Lukacs, Nicholas W.; Boushey, Homer A.; Ownby, Dennis Randall; Lynch, Susan V.; Johnson, Christine C.

In: Scientific Reports, Vol. 6, 31775, 25.08.2016.

Research output: Contribution to journalArticle

Levin, AM, Sitarik, AR, Havstad, SL, Fujimura, KE, Wegienka, G, Cassidy-Bushrow, AE, Kim, H, Zoratti, EM, Lukacs, NW, Boushey, HA, Ownby, DR, Lynch, SV & Johnson, CC 2016, 'Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity', Scientific Reports, vol. 6, 31775. https://doi.org/10.1038/srep31775
Levin, Albert M. ; Sitarik, Alexandra R. ; Havstad, Suzanne L. ; Fujimura, Kei E. ; Wegienka, Ganesa ; Cassidy-Bushrow, Andrea E. ; Kim, Haejin ; Zoratti, Edward M. ; Lukacs, Nicholas W. ; Boushey, Homer A. ; Ownby, Dennis Randall ; Lynch, Susan V. ; Johnson, Christine C. / Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity. In: Scientific Reports. 2016 ; Vol. 6.
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