Karyotyping of candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis

Jose Antonio Vazquez, Jack D. Sobel, Robert Demitriou, Julie Vaishampayan, Maria Lynch, Marcus J. Zervos

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Ten women with recurrent vulvovaginal candidiasis (RVVC) due to Candida albicans were followed for a mean of 35.3 months, and 81 vaginal isolates were evaluated by pulsed-field gel electrophoresis for strain delineation. The initial strain of C. albicans isolated was unique to each patient; in addition, in 8 women, only 1 strain type of C. albicans was identified throughout follow-up. In 1 patient, 3 strains of C. albicans were identified over a 27-month period and in another, 2 strains were recovered over a 3D-month period. Two pairs of women shared identical strains of C. albicans. These results confirm the enormous diversity of strain types of C. albicans and demonstrate the persistence of colonization with the same strain over prolonged periods despite therapy. Results also support the concept of recurrent vaginitis being due to vaginal relapse or endogenous reinfection with the identical strain.

Original languageEnglish (US)
Pages (from-to)1566-1569
Number of pages4
JournalJournal of Infectious Diseases
Volume170
Issue number6
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Vulvovaginal Candidiasis
Karyotyping
Candida albicans
Vaginitis
Pulsed Field Gel Electrophoresis
Recurrence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Karyotyping of candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis. / Vazquez, Jose Antonio; Sobel, Jack D.; Demitriou, Robert; Vaishampayan, Julie; Lynch, Maria; Zervos, Marcus J.

In: Journal of Infectious Diseases, Vol. 170, No. 6, 01.01.1994, p. 1566-1569.

Research output: Contribution to journalArticle

Vazquez, Jose Antonio ; Sobel, Jack D. ; Demitriou, Robert ; Vaishampayan, Julie ; Lynch, Maria ; Zervos, Marcus J. / Karyotyping of candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis. In: Journal of Infectious Diseases. 1994 ; Vol. 170, No. 6. pp. 1566-1569.
@article{2d6e7fb792e64ad19bd5bd84c9d70d14,
title = "Karyotyping of candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis",
abstract = "Ten women with recurrent vulvovaginal candidiasis (RVVC) due to Candida albicans were followed for a mean of 35.3 months, and 81 vaginal isolates were evaluated by pulsed-field gel electrophoresis for strain delineation. The initial strain of C. albicans isolated was unique to each patient; in addition, in 8 women, only 1 strain type of C. albicans was identified throughout follow-up. In 1 patient, 3 strains of C. albicans were identified over a 27-month period and in another, 2 strains were recovered over a 3D-month period. Two pairs of women shared identical strains of C. albicans. These results confirm the enormous diversity of strain types of C. albicans and demonstrate the persistence of colonization with the same strain over prolonged periods despite therapy. Results also support the concept of recurrent vaginitis being due to vaginal relapse or endogenous reinfection with the identical strain.",
author = "Vazquez, {Jose Antonio} and Sobel, {Jack D.} and Robert Demitriou and Julie Vaishampayan and Maria Lynch and Zervos, {Marcus J.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1093/infdis/170.6.1566",
language = "English (US)",
volume = "170",
pages = "1566--1569",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Karyotyping of candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis

AU - Vazquez, Jose Antonio

AU - Sobel, Jack D.

AU - Demitriou, Robert

AU - Vaishampayan, Julie

AU - Lynch, Maria

AU - Zervos, Marcus J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Ten women with recurrent vulvovaginal candidiasis (RVVC) due to Candida albicans were followed for a mean of 35.3 months, and 81 vaginal isolates were evaluated by pulsed-field gel electrophoresis for strain delineation. The initial strain of C. albicans isolated was unique to each patient; in addition, in 8 women, only 1 strain type of C. albicans was identified throughout follow-up. In 1 patient, 3 strains of C. albicans were identified over a 27-month period and in another, 2 strains were recovered over a 3D-month period. Two pairs of women shared identical strains of C. albicans. These results confirm the enormous diversity of strain types of C. albicans and demonstrate the persistence of colonization with the same strain over prolonged periods despite therapy. Results also support the concept of recurrent vaginitis being due to vaginal relapse or endogenous reinfection with the identical strain.

AB - Ten women with recurrent vulvovaginal candidiasis (RVVC) due to Candida albicans were followed for a mean of 35.3 months, and 81 vaginal isolates were evaluated by pulsed-field gel electrophoresis for strain delineation. The initial strain of C. albicans isolated was unique to each patient; in addition, in 8 women, only 1 strain type of C. albicans was identified throughout follow-up. In 1 patient, 3 strains of C. albicans were identified over a 27-month period and in another, 2 strains were recovered over a 3D-month period. Two pairs of women shared identical strains of C. albicans. These results confirm the enormous diversity of strain types of C. albicans and demonstrate the persistence of colonization with the same strain over prolonged periods despite therapy. Results also support the concept of recurrent vaginitis being due to vaginal relapse or endogenous reinfection with the identical strain.

UR - http://www.scopus.com/inward/record.url?scp=0028143732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028143732&partnerID=8YFLogxK

U2 - 10.1093/infdis/170.6.1566

DO - 10.1093/infdis/170.6.1566

M3 - Article

VL - 170

SP - 1566

EP - 1569

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -