Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China

Bo feng Zhu, Hong dan Wang, Chun mei Shen, Ya jun Deng, Guang Yang, Qing ju Wu, Peng Xu, Hai xia Qin, Shuan liang Fan, Ping Huang, Li bin Deng, Rudolf Lucas, Zhen Yuan Wang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to analyze killer immunoglobulin-like receptor (KIR) gene polymorphisms in the Tibetan ethnic minority of China. To that purpose, we have studied KIR gene frequencies and genotype diversities of 16 KIR genes and three pseudogenes (2DL1, 2DL2, 2DL3, 2DL4, 2DL5A, 2DL5B, 2DS1, 2DS2, 2DS3, 2DS4*001/002, 2DS4*003-007, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1*001/002/004, and 3DP1*003) in a population sample of 102 unrelated healthy individuals of the Tibetan population living in Lhasa city, Tibet Autonomous Region of China. Tibetans mainly live in "the roof of the world," the Qinghai-Tibet Plateau of China and surrounding areas stretching from central Asia in the North and West to Myanmar and mainland China in the East, and India, Nepal, and Bhutan to the south. KIR gene frequencies and statistical parameters of Tibetan ethnic minority were calculated. Fifteen KIR genes were observed in the 102 tested Tibetan individuals with different frequencies. The allelic frequencies of the 15 KIR genes ranged from 0.06 to 0.86. In addition, KIR 2DL1, 2DL4, 3DL2, and 3DL3 were found to be present in every individual. Variable gene content, together with allelic polymorphisms, can result in individualized human KIR genotypes and haplotypes, with the A haplotypes being predominantly observed. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Moreover, a comparison of the population data of our study with previously published population data of other ethnic groups or areas was performed. The differences of allelic frequency distribution in KIR2DL2, 2DL3, 2DL5, 3DL1, 2DS1, 2DS2, 2DS3, 3DS1, and 2DP1 were statistically significant among different populations using the statistical method of the standard χ2 test. In conclusion, the results of the present study can be valuable for enriching the Chinese ethnical gene information resources of the KIR gene pool and for anthological studies, as well as for KIR-related disease research.

Original languageEnglish (US)
Pages (from-to)1116-1123
Number of pages8
JournalHuman Immunology
Volume71
Issue number11
DOIs
StatePublished - Nov 1 2010

Fingerprint

KIR Receptors
Minority Groups
Ethnic Groups
China
Genes
Tibet
Population
Linkage Disequilibrium
Gene Frequency
Haplotypes
Bhutan
Genotype
Central Asia
Myanmar
Gene Pool
Nepal
Pseudogenes
India

Keywords

  • KIR
  • LD
  • PCR-SSP
  • Tibetan ethnic group

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Zhu, B. F., Wang, H. D., Shen, C. M., Deng, Y. J., Yang, G., Wu, Q. J., ... Wang, Z. Y. (2010). Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China. Human Immunology, 71(11), 1116-1123. https://doi.org/10.1016/j.humimm.2010.07.010

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China. / Zhu, Bo feng; Wang, Hong dan; Shen, Chun mei; Deng, Ya jun; Yang, Guang; Wu, Qing ju; Xu, Peng; Qin, Hai xia; Fan, Shuan liang; Huang, Ping; Deng, Li bin; Lucas, Rudolf; Wang, Zhen Yuan.

In: Human Immunology, Vol. 71, No. 11, 01.11.2010, p. 1116-1123.

Research output: Contribution to journalArticle

Zhu, BF, Wang, HD, Shen, CM, Deng, YJ, Yang, G, Wu, QJ, Xu, P, Qin, HX, Fan, SL, Huang, P, Deng, LB, Lucas, R & Wang, ZY 2010, 'Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China', Human Immunology, vol. 71, no. 11, pp. 1116-1123. https://doi.org/10.1016/j.humimm.2010.07.010
Zhu, Bo feng ; Wang, Hong dan ; Shen, Chun mei ; Deng, Ya jun ; Yang, Guang ; Wu, Qing ju ; Xu, Peng ; Qin, Hai xia ; Fan, Shuan liang ; Huang, Ping ; Deng, Li bin ; Lucas, Rudolf ; Wang, Zhen Yuan. / Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China. In: Human Immunology. 2010 ; Vol. 71, No. 11. pp. 1116-1123.
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