Label-free analysis of DNA methylation using optofluidic ring resonators

Jonathan D. Suter, Daniel J. Howard, Huidong Shi, Charles W. Caldwell, Xudong Fan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We demonstrate the utility of the opto-fluidic ring resonator (OFRR) sensor for analyzing methylated oligonucleotides. Cytosine methylation, a regular epigenetic function in cellular growth and metabolism, may have ties to abnormal suppression of key genes involved with cellular proliferation. Such behavior is suspected to be strongly related to the occurrence of several types of cancers. The OFRR is demonstrated as a tool both for detecting DNA hybridization and methylated cytosines residues.

Original languageEnglish (US)
Title of host publicationproceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society:
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC
PublisherIEEE Computer Society
Pages2760-2762
Number of pages3
ISBN (Print)9781424432967
DOIs
Publication statusPublished - Dec 1 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

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ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Suter, J. D., Howard, D. J., Shi, H., Caldwell, C. W., & Fan, X. (2009). Label-free analysis of DNA methylation using optofluidic ring resonators. In proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC (pp. 2760-2762). [5333866] (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5333866