Label-free analysis of DNA methylation using optofluidic ring resonators

Jonathan D. Suter; Daniel J. Howard; Huidong Shi; Charles W. Caldwell; Xudong Fan

doi:10.1109/IEMBS.2009.5333866

Label-free analysis of DNA methylation using optofluidic ring resonators

Jonathan D. Suter, Daniel J. Howard, Huidong Shi, Charles W. Caldwell, Xudong Fan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

We demonstrate the utility of the opto-fluidic ring resonator (OFRR) sensor for analyzing methylated oligonucleotides. Cytosine methylation, a regular epigenetic function in cellular growth and metabolism, may have ties to abnormal suppression of key genes involved with cellular proliferation. Such behavior is suspected to be strongly related to the occurrence of several types of cancers. The OFRR is demonstrated as a tool both for detecting DNA hybridization and methylated cytosines residues.

Original language	English (US)
Title of host publication	proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society:
Subtitle of host publication	Engineering the Future of Biomedicine, EMBC
Publisher	IEEE Computer Society
Pages	2760-2762
Number of pages	3
ISBN (Print)	9781424432967
DOIs	https://doi.org/10.1109/IEMBS.2009.5333866
State	Published - Dec 1 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

Publication series

Name	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country/Territory	United States
City	Minneapolis, MN
Period	9/2/09 → 9/6/09

ASJC Scopus subject areas

Cell Biology
Developmental Biology
Biomedical Engineering
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/IEMBS.2009.5333866

Cite this

Suter, J. D., Howard, D. J., Shi, H., Caldwell, C. W., & Fan, X. (2009). Label-free analysis of DNA methylation using optofluidic ring resonators. In proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC (pp. 2760-2762). Article 5333866 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5333866

Label-free analysis of DNA methylation using optofluidic ring resonators. / Suter, Jonathan D.; Howard, Daniel J.; Shi, Huidong et al.
proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC. IEEE Computer Society, 2009. p. 2760-2762 5333866 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Suter, JD, Howard, DJ, Shi, H, Caldwell, CW & Fan, X 2009, Label-free analysis of DNA methylation using optofluidic ring resonators. in proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC., 5333866, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, IEEE Computer Society, pp. 2760-2762, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5333866

Suter JD, Howard DJ, Shi H, Caldwell CW, Fan X. Label-free analysis of DNA methylation using optofluidic ring resonators. In proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC. IEEE Computer Society. 2009. p. 2760-2762. 5333866. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). doi: 10.1109/IEMBS.2009.5333866

Suter, Jonathan D. ; Howard, Daniel J. ; Shi, Huidong et al. / Label-free analysis of DNA methylation using optofluidic ring resonators. proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: : Engineering the Future of Biomedicine, EMBC. IEEE Computer Society, 2009. pp. 2760-2762 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

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Label-free analysis of DNA methylation using optofluidic ring resonators

Abstract

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ASJC Scopus subject areas

UN SDGs

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