Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

Xiaofan Mi, Hongzhi He, Yangxin Deng, Abert M. Levin, Jin-Xiong She, Qing Sheng Mi, Li Zhou

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Abstract. MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.

Original languageEnglish (US)
Article number27
JournalDiabetology and Metabolic Syndrome
Volume3
Issue number1
DOIs
StatePublished - Oct 21 2011

Fingerprint

Type 1 Diabetes Mellitus
Single Nucleotide Polymorphism
MicroRNAs
Interleukin-16
Small Untranslated RNA
Interleukin-17
Protein Biosynthesis
Genes
Insulin-Dependent Diabetes Mellitus 10

Keywords

  • Type 1 diabetes
  • microRNAs
  • polymorphism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes. / Mi, Xiaofan; He, Hongzhi; Deng, Yangxin; Levin, Abert M.; She, Jin-Xiong; Mi, Qing Sheng; Zhou, Li.

In: Diabetology and Metabolic Syndrome, Vol. 3, No. 1, 27, 21.10.2011.

Research output: Contribution to journalArticle

Mi, Xiaofan ; He, Hongzhi ; Deng, Yangxin ; Levin, Abert M. ; She, Jin-Xiong ; Mi, Qing Sheng ; Zhou, Li. / Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes. In: Diabetology and Metabolic Syndrome. 2011 ; Vol. 3, No. 1.
@article{939b3b4133fe422bbae8ed02c028909f,
title = "Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes",
abstract = "Abstract. MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.",
keywords = "Type 1 diabetes, microRNAs, polymorphism",
author = "Xiaofan Mi and Hongzhi He and Yangxin Deng and Levin, {Abert M.} and Jin-Xiong She and Mi, {Qing Sheng} and Li Zhou",
year = "2011",
month = "10",
day = "21",
doi = "10.1186/1758-5996-3-27",
language = "English (US)",
volume = "3",
journal = "Diabetology and Metabolic Syndrome",
issn = "1758-5996",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

AU - Mi, Xiaofan

AU - He, Hongzhi

AU - Deng, Yangxin

AU - Levin, Abert M.

AU - She, Jin-Xiong

AU - Mi, Qing Sheng

AU - Zhou, Li

PY - 2011/10/21

Y1 - 2011/10/21

N2 - Abstract. MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.

AB - Abstract. MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.

KW - Type 1 diabetes

KW - microRNAs

KW - polymorphism

UR - http://www.scopus.com/inward/record.url?scp=80054709951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054709951&partnerID=8YFLogxK

U2 - 10.1186/1758-5996-3-27

DO - 10.1186/1758-5996-3-27

M3 - Article

C2 - 22014115

AN - SCOPUS:80054709951

VL - 3

JO - Diabetology and Metabolic Syndrome

JF - Diabetology and Metabolic Syndrome

SN - 1758-5996

IS - 1

M1 - 27

ER -