Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

Xiaofan Mi, Hongzhi He, Yangxin Deng, Abert M. Levin, Jin-Xiong She, Qing Sheng Mi, Li Zhou

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Abstract. MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.

Original languageEnglish (US)
Article number27
JournalDiabetology and Metabolic Syndrome
Volume3
Issue number1
DOIs
Publication statusPublished - Oct 21 2011

    Fingerprint

Keywords

  • Type 1 diabetes
  • microRNAs
  • polymorphism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this