Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA

D. Meruelo, R. Kornreich, A. Rossomando, C. Pampeno, A. Boral, J. L. Silver, J. Buxbaum, E. H. Weiss, J. J. Devlin, A. L. Mellor

Research output: Contribution to journalArticle

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Abstract

Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibility genes.

Original languageEnglish (US)
Pages (from-to)4504-4508
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number12
DOIs
StatePublished - Jan 1 1986

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Radiation Leukemia Virus
H-2 Antigens
Histocompatibility Antigens Class I
Major Histocompatibility Complex
Methylation
Histocompatibility
Viral Genome
Thymocytes
Viruses
DNA
Enzymes
Genes
triplex DNA

ASJC Scopus subject areas

  • General

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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. / Meruelo, D.; Kornreich, R.; Rossomando, A.; Pampeno, C.; Boral, A.; Silver, J. L.; Buxbaum, J.; Weiss, E. H.; Devlin, J. J.; Mellor, A. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 12, 01.01.1986, p. 4504-4508.

Research output: Contribution to journalArticle

Meruelo, D. ; Kornreich, R. ; Rossomando, A. ; Pampeno, C. ; Boral, A. ; Silver, J. L. ; Buxbaum, J. ; Weiss, E. H. ; Devlin, J. J. ; Mellor, A. L. / Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. In: Proceedings of the National Academy of Sciences of the United States of America. 1986 ; Vol. 83, No. 12. pp. 4504-4508.
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AU - Boral, A.

AU - Silver, J. L.

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AU - Weiss, E. H.

AU - Devlin, J. J.

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