Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA

D. Meruelo, R. Kornreich, A. Rossomando, C. Pampeno, A. Boral, J. L. Silver, J. Buxbaum, E. H. Weiss, J. J. Devlin, A. L. Mellor

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Abstract

Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibility genes.

Original languageEnglish (US)
Pages (from-to)4504-4508
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number12
DOIs
Publication statusPublished - Jan 1 1986

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