Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype

William H. Hoffman, Sandra W Helman, Elizabeth Sekul, James Edwin Carroll, Roger A. Vega

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report on a child with a family history of autoimmune defects, who presented at the age of 3 1/2 years with alopecia and Graves disease. He subsequently developed vitiligo and psoriasis. At 9 1/2 years, he developed an autoimmune form of Lambert-Eaton Myasthenic syndrome (LEMS) with a significant elevation of glutamic acid decarboxylase (GAD) autoantibodies. Shortly thereafter he developed chronic urticaria. HLA associations were present for Graves disease, vitiligo, psoriasis, and IgA deficiency. There was also evidence of autoimmunity involving the pancreatic islet cells and gastric parietal cells.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume119 A
Issue number1
StatePublished - May 15 2003

Fingerprint

Lambert-Eaton Myasthenic Syndrome
Vitiligo
Graves Disease
Islets of Langerhans
Psoriasis
Gastric Parietal Cells
IgA Deficiency
Phenotype
Glutamate Decarboxylase
Alopecia
Urticaria
Autoimmunity
Autoantibodies

Keywords

  • Autoimmune polyglandular syndrome
  • GAD autoantibody
  • Graves disease
  • HLA
  • Lambert-Eaton Myasthenic syndrome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype. / Hoffman, William H.; Helman, Sandra W; Sekul, Elizabeth; Carroll, James Edwin; Vega, Roger A.

In: American Journal of Medical Genetics, Vol. 119 A, No. 1, 15.05.2003, p. 77-80.

Research output: Contribution to journalArticle

Hoffman, William H. ; Helman, Sandra W ; Sekul, Elizabeth ; Carroll, James Edwin ; Vega, Roger A. / Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype. In: American Journal of Medical Genetics. 2003 ; Vol. 119 A, No. 1. pp. 77-80.
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