Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10

Botond Z. Igyarto, Matthew C. Jenison, Jan C. Dudda, Axel Roers, Werner Müller, Pandelakis A. Koni, Daniel J. Campbell, Mark J. Shlomchik, Daniel H. Kaplan

Research output: Contribution to journalArticle

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Abstract

Mice lacking epidermal Langerhans cells (LC) develop exaggerated contact-hypersensitivity (CHS) responses due to the absence of LC during sensitization/initiation. Examination of T cell responses reveals that the absence of LC leads to increased numbers of hapten-specific CD4 and CD8 T cells but does not alter cytokine expression or development of T regulatory cells. CHS responses and Ag-specific T cells are increased in mice in which MHC class II is ablated specifically in LC suggesting that direct cognate interaction between LC and CD4 cells is required for suppression. LC-derived IL-10 is also required for optimal inhibition of CHS. Both LC-derived IL-10-mediated suppression and full LC activation require LC expression of MHC class II. These data support a model in which cognate interaction of LC with CD4 T cells enables LC to inhibit expansion of Ag-specific responses via elaboration of IL-10.

Original languageEnglish (US)
Pages (from-to)5085-5093
Number of pages9
JournalJournal of Immunology
Volume183
Issue number8
DOIs
StatePublished - Oct 15 2009

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Langerhans Cells
Contact Dermatitis
Interleukin-10
T-Lymphocytes
Haptens
Regulatory T-Lymphocytes
Cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Igyarto, B. Z., Jenison, M. C., Dudda, J. C., Roers, A., Müller, W., Koni, P. A., ... Kaplan, D. H. (2009). Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. Journal of Immunology, 183(8), 5085-5093. https://doi.org/10.4049/jimmunol.0901884

Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. / Igyarto, Botond Z.; Jenison, Matthew C.; Dudda, Jan C.; Roers, Axel; Müller, Werner; Koni, Pandelakis A.; Campbell, Daniel J.; Shlomchik, Mark J.; Kaplan, Daniel H.

In: Journal of Immunology, Vol. 183, No. 8, 15.10.2009, p. 5085-5093.

Research output: Contribution to journalArticle

Igyarto, BZ, Jenison, MC, Dudda, JC, Roers, A, Müller, W, Koni, PA, Campbell, DJ, Shlomchik, MJ & Kaplan, DH 2009, 'Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10', Journal of Immunology, vol. 183, no. 8, pp. 5085-5093. https://doi.org/10.4049/jimmunol.0901884
Igyarto, Botond Z. ; Jenison, Matthew C. ; Dudda, Jan C. ; Roers, Axel ; Müller, Werner ; Koni, Pandelakis A. ; Campbell, Daniel J. ; Shlomchik, Mark J. ; Kaplan, Daniel H. / Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. In: Journal of Immunology. 2009 ; Vol. 183, No. 8. pp. 5085-5093.
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