Laryngeal chondrosarcoma: A systematic review of 592 cases

Oliver Y. Chin, Pariket M. Dubal, Ahmed B. Sheikh, Aykut A. Unsal, Richard Chan Woo Park, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives/Hypothesis: Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes. Study Design: Systematic review using PubMed/MEDLINE and EMBASE database. Methods: The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow-up. Results: Five hundred and ninety-two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease-specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5-year survival rates for location, grade, and therapy. Conclusion: Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5-year survival outcomes. Nonsurgical approaches were rarely used for these lesions. Level of Evidence: N/A. Laryngoscope, 2016 127:430–439, 2017.

Original languageEnglish (US)
Pages (from-to)430-439
Number of pages10
JournalLaryngoscope
Volume127
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Chondrosarcoma
Larynx
Laryngectomy
Survival Rate
Arytenoid Cartilage
Cricoid Cartilage
Thyroid Cartilage
Databases
Epiglottis
Laryngoscopes
Therapeutics
PubMed
MEDLINE
Neoplasms
Radiotherapy
Demography
Pathology
Drug Therapy
Survival

Keywords

  • Larynx chondrosarcoma
  • cartilaginous tumor
  • chondrosarcomas
  • laryngeal cancer
  • laryngeal chondrosarcoma
  • laryngeal malignancy
  • laryngeal tumor
  • larynx cancer
  • larynx malignancy
  • systematic review

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Chin, O. Y., Dubal, P. M., Sheikh, A. B., Unsal, A. A., Park, R. C. W., Baredes, S., & Eloy, J. A. (2017). Laryngeal chondrosarcoma: A systematic review of 592 cases. Laryngoscope, 127(2), 430-439. https://doi.org/10.1002/lary.26068

Laryngeal chondrosarcoma : A systematic review of 592 cases. / Chin, Oliver Y.; Dubal, Pariket M.; Sheikh, Ahmed B.; Unsal, Aykut A.; Park, Richard Chan Woo; Baredes, Soly; Eloy, Jean Anderson.

In: Laryngoscope, Vol. 127, No. 2, 01.02.2017, p. 430-439.

Research output: Contribution to journalArticle

Chin, OY, Dubal, PM, Sheikh, AB, Unsal, AA, Park, RCW, Baredes, S & Eloy, JA 2017, 'Laryngeal chondrosarcoma: A systematic review of 592 cases', Laryngoscope, vol. 127, no. 2, pp. 430-439. https://doi.org/10.1002/lary.26068
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RCW, Baredes S et al. Laryngeal chondrosarcoma: A systematic review of 592 cases. Laryngoscope. 2017 Feb 1;127(2):430-439. https://doi.org/10.1002/lary.26068
Chin, Oliver Y. ; Dubal, Pariket M. ; Sheikh, Ahmed B. ; Unsal, Aykut A. ; Park, Richard Chan Woo ; Baredes, Soly ; Eloy, Jean Anderson. / Laryngeal chondrosarcoma : A systematic review of 592 cases. In: Laryngoscope. 2017 ; Vol. 127, No. 2. pp. 430-439.
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abstract = "Objectives/Hypothesis: Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes. Study Design: Systematic review using PubMed/MEDLINE and EMBASE database. Methods: The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow-up. Results: Five hundred and ninety-two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8{\%} and 0.2{\%}, respectively. Disease-specific survival rates for 1, 5, 10, and 20 years were 97.7{\%}, 91.4{\%}, 81.8{\%}, and 68.0{\%}, respectively, with no differences when comparing 5-year survival rates for location, grade, and therapy. Conclusion: Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5-year survival outcomes. Nonsurgical approaches were rarely used for these lesions. Level of Evidence: N/A. Laryngoscope, 2016 127:430–439, 2017.",
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