TY - JOUR
T1 - Laryngeal chondrosarcoma
T2 - A systematic review of 592 cases
AU - Chin, Oliver Y.
AU - Dubal, Pariket M.
AU - Sheikh, Ahmed B.
AU - Unsal, Aykut A.
AU - Park, Richard Chan Woo
AU - Baredes, Soly
AU - Eloy, Jean Anderson
N1 - Publisher Copyright:
© 2016 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objectives/Hypothesis: Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes. Study Design: Systematic review using PubMed/MEDLINE and EMBASE database. Methods: The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow-up. Results: Five hundred and ninety-two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease-specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5-year survival rates for location, grade, and therapy. Conclusion: Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5-year survival outcomes. Nonsurgical approaches were rarely used for these lesions. Level of Evidence: N/A. Laryngoscope, 2016 127:430–439, 2017.
AB - Objectives/Hypothesis: Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes. Study Design: Systematic review using PubMed/MEDLINE and EMBASE database. Methods: The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow-up. Results: Five hundred and ninety-two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease-specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5-year survival rates for location, grade, and therapy. Conclusion: Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5-year survival outcomes. Nonsurgical approaches were rarely used for these lesions. Level of Evidence: N/A. Laryngoscope, 2016 127:430–439, 2017.
KW - Larynx chondrosarcoma
KW - cartilaginous tumor
KW - chondrosarcomas
KW - laryngeal cancer
KW - laryngeal chondrosarcoma
KW - laryngeal malignancy
KW - laryngeal tumor
KW - larynx cancer
KW - larynx malignancy
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=84978372509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978372509&partnerID=8YFLogxK
U2 - 10.1002/lary.26068
DO - 10.1002/lary.26068
M3 - Article
C2 - 27291822
AN - SCOPUS:84978372509
SN - 0023-852X
VL - 127
SP - 430
EP - 439
JO - Laryngoscope
JF - Laryngoscope
IS - 2
ER -