Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure

A possible model for sudden infant death syndrome

S. G. Duke, Gregory N Postma, W. F. McGuirt, D. Ririe, D. B. Averill, J. A. Koufman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Laryngopharyngeal reflux has been proposed as a possible cause of sudden infant death syndrome (SIDS). We investigated the efferent laryngeal and diaphragmatic responses to acid exposure on the laryngeal mucosa using a neonatal canine model. Electromyographic (EMG) recordings from the thyroarytenoid muscle and the diaphragm were measured with hooked-wire electrodes. Reproducible laryngospasm responses occurred in all animals after laryngeal exposure to hydrochloric acid at pH 2.0 or less. Laryngospasm occurred in combination with tachypnea and increased diaphragmatic activity in most of the animals. Laryngospasm was associated with prolonged apnea and total cessation of diaphragmatic EMG activity in 1 animal, and in another, initial tachypnea was followed by erratic diaphragmatic activity and brief apnea. Laryngeal acid exposure (below pH 2.0) causes laryngospasm and may result in paradoxical apneic events in neonatal dogs. Acid-induced, laryngospasm-associated apnea may represent a potential cause of SIDS, and the immature dog appears to be an excellent model for further investigations.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume110
Issue number8
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Laryngismus
Sudden Infant Death
Dogs
Apnea
Acids
Tachypnea
Laryngopharyngeal Reflux
Laryngeal Mucosa
Laryngeal Muscles
Hydrochloric Acid
Diaphragm
Canidae
Electrodes

Keywords

  • Apnea
  • Crib death
  • Dog
  • Electromyography
  • Gastroesophageal reflux
  • Infant death
  • Laryngeal reflexes
  • Laryngopharyngeal reflux
  • Laryngospasm
  • Larynx
  • Reflux
  • Sudden infant death syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure : A possible model for sudden infant death syndrome. / Duke, S. G.; Postma, Gregory N; McGuirt, W. F.; Ririe, D.; Averill, D. B.; Koufman, J. A.

In: Annals of Otology, Rhinology and Laryngology, Vol. 110, No. 8, 01.01.2001, p. 729-733.

Research output: Contribution to journalArticle

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