Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD

Sreedharan Sajikumar, Julietta Uta Frey

Research output: Contribution to journalArticle

235 Scopus citations

Abstract

Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'

Original languageEnglish (US)
Pages (from-to)12-25
Number of pages14
JournalNeurobiology of Learning and Memory
Volume82
Issue number1
DOIs
StatePublished - Jul 1 2004

Keywords

  • Cross-tagging
  • Heterosynaptic late-associativity
  • Long-term depression
  • Long-term potentiation
  • Protein synthesis
  • Synaptic tagging

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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