Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD

Sreedharan Sajikumar, Julietta Uta Frey

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'

Original languageEnglish (US)
Pages (from-to)12-25
Number of pages14
JournalNeurobiology of Learning and Memory
Volume82
Issue number1
DOIs
StatePublished - Jul 1 2004

Fingerprint

Long-Term Potentiation
Dopamine
Depression
Synapses
Proteins
Automatic Data Processing
Names

Keywords

  • Cross-tagging
  • Heterosynaptic late-associativity
  • Long-term depression
  • Long-term potentiation
  • Protein synthesis
  • Synaptic tagging

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD. / Sajikumar, Sreedharan; Frey, Julietta Uta.

In: Neurobiology of Learning and Memory, Vol. 82, No. 1, 01.07.2004, p. 12-25.

Research output: Contribution to journalArticle

Sajikumar, Sreedharan ; Frey, Julietta Uta. / Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD. In: Neurobiology of Learning and Memory. 2004 ; Vol. 82, No. 1. pp. 12-25.
@article{de1fd049e74443f195c5c9c6474e8dc8,
title = "Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD",
abstract = "Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'",
keywords = "Cross-tagging, Heterosynaptic late-associativity, Long-term depression, Long-term potentiation, Protein synthesis, Synaptic tagging",
author = "Sreedharan Sajikumar and Frey, {Julietta Uta}",
year = "2004",
month = "7",
day = "1",
doi = "10.1016/j.nlm.2004.03.003",
language = "English (US)",
volume = "82",
pages = "12--25",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD

AU - Sajikumar, Sreedharan

AU - Frey, Julietta Uta

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'

AB - Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'

KW - Cross-tagging

KW - Heterosynaptic late-associativity

KW - Long-term depression

KW - Long-term potentiation

KW - Protein synthesis

KW - Synaptic tagging

UR - http://www.scopus.com/inward/record.url?scp=2942528888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942528888&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2004.03.003

DO - 10.1016/j.nlm.2004.03.003

M3 - Article

VL - 82

SP - 12

EP - 25

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -