Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD

Sreedharan Sajikumar, Julietta U. Frey

Research output: Contribution to journalArticlepeer-review

271 Scopus citations


Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation (LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it was described that the induction of LTP can mark a specifically activated synapse by a synaptic tag to capture synapse non-specific plasticity-related proteins (PRPs) and thus maintaining input-specific LTP for prolonged periods. Here we show in rat hippocampal slices in vitro, that the induction of protein synthesis-dependent late-LTD is also characterized by synaptic tagging and that heterosynaptic induction of either LTD or LTP on two sets of independent synaptic inputs S1 and S2 can lead to late-associative interactions: early-LTD in S2 was transformed into a late-LTD, if late-LTP was induced in S1. The synthesis of process-independent PRPs by late-LTP in S1 was sufficient to transform early- into late-LTD in S2 when process-specific synaptic tags were set. We name this new associative property of cellular information processing 'cross-tagging.'

Original languageEnglish (US)
Pages (from-to)12-25
Number of pages14
JournalNeurobiology of Learning and Memory
Issue number1
StatePublished - Jul 2004


  • Cross-tagging
  • Heterosynaptic late-associativity
  • Long-term depression
  • Long-term potentiation
  • Protein synthesis
  • Synaptic tagging

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


Dive into the research topics of 'Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD'. Together they form a unique fingerprint.

Cite this