Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI: A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics

Jacob U. Fluckiger, Jeffrey J. Goldberger, Daniel C. Lee, Jason Ng, Richard Lee, Amita Goyal, Michael Markl

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: To use four-dimensional (4D) flow MRI to characterize and quantify 3D blood flow in the left atria (LA) of patients with a history of atrial fibrillation (AF). Materials and Methods: The 4D flow MRI was acquired in 19 volunteers (n = 9<30 years, n = 10>50 years) and 10 patients with AF (62 ± 9.6 years; n = 4 in persistent AF, n = 6postintervention). The LA in each dataset was segmented, and intra-atrial blood flow velocity was quantified. Flow coherence was measured as the consistency of the net blood flow vector. Results: Quantification of atrial flow revealed significant differences in atrial hemodynamics between age groups. Postintervention AF patients had a mean blood flow of 0.22 ± 0.04 m/s, which was not significantly different than age-matched volunteers (0.21 ± 0.03 m/s). Patients with persistent AF had a mean blood flow of 0.13 ± 0.01 m/s, lower than AF patients in sinus rhythm (0.22 ± 0.04 m/s, P = 0.005), or age-matched volunteers (0.21 ± 0.03 m/s, P < 0.001). Flow coherence was significantly impaired in patients in AF. Conclusion: Flow-sensitive MRI shows that patients with a history of AF had global hemodynamics in the LA similar to those of age-matched volunteers. Additional studies with larger cohorts of AF patients and correlation with outcome are needed to further investigate the potential of atrial 4D flow MRI to flow patterns indicative of stroke risk in AF.

Original languageEnglish (US)
Pages (from-to)580-587
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number3
DOIs
StatePublished - Sep 1 2013

Fingerprint

Atrial Fibrillation
Hemodynamics
Volunteers
Heart Atria
Blood Flow Velocity
Age Groups
Stroke

Keywords

  • 4D flow MRI
  • Atrial fibrillation
  • cardiac magnetic resonance
  • flow imaging
  • flow quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI : A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics. / Fluckiger, Jacob U.; Goldberger, Jeffrey J.; Lee, Daniel C.; Ng, Jason; Lee, Richard; Goyal, Amita; Markl, Michael.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 3, 01.09.2013, p. 580-587.

Research output: Contribution to journalArticle

@article{760537eeb3f74a64a24f173a9e6fa058,
title = "Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI: A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics",
abstract = "Purpose: To use four-dimensional (4D) flow MRI to characterize and quantify 3D blood flow in the left atria (LA) of patients with a history of atrial fibrillation (AF). Materials and Methods: The 4D flow MRI was acquired in 19 volunteers (n = 9<30 years, n = 10>50 years) and 10 patients with AF (62 ± 9.6 years; n = 4 in persistent AF, n = 6postintervention). The LA in each dataset was segmented, and intra-atrial blood flow velocity was quantified. Flow coherence was measured as the consistency of the net blood flow vector. Results: Quantification of atrial flow revealed significant differences in atrial hemodynamics between age groups. Postintervention AF patients had a mean blood flow of 0.22 ± 0.04 m/s, which was not significantly different than age-matched volunteers (0.21 ± 0.03 m/s). Patients with persistent AF had a mean blood flow of 0.13 ± 0.01 m/s, lower than AF patients in sinus rhythm (0.22 ± 0.04 m/s, P = 0.005), or age-matched volunteers (0.21 ± 0.03 m/s, P < 0.001). Flow coherence was significantly impaired in patients in AF. Conclusion: Flow-sensitive MRI shows that patients with a history of AF had global hemodynamics in the LA similar to those of age-matched volunteers. Additional studies with larger cohorts of AF patients and correlation with outcome are needed to further investigate the potential of atrial 4D flow MRI to flow patterns indicative of stroke risk in AF.",
keywords = "4D flow MRI, Atrial fibrillation, cardiac magnetic resonance, flow imaging, flow quantification",
author = "Fluckiger, {Jacob U.} and Goldberger, {Jeffrey J.} and Lee, {Daniel C.} and Jason Ng and Richard Lee and Amita Goyal and Michael Markl",
year = "2013",
month = "9",
day = "1",
doi = "10.1002/jmri.23994",
language = "English (US)",
volume = "38",
pages = "580--587",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI

T2 - A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics

AU - Fluckiger, Jacob U.

AU - Goldberger, Jeffrey J.

AU - Lee, Daniel C.

AU - Ng, Jason

AU - Lee, Richard

AU - Goyal, Amita

AU - Markl, Michael

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Purpose: To use four-dimensional (4D) flow MRI to characterize and quantify 3D blood flow in the left atria (LA) of patients with a history of atrial fibrillation (AF). Materials and Methods: The 4D flow MRI was acquired in 19 volunteers (n = 9<30 years, n = 10>50 years) and 10 patients with AF (62 ± 9.6 years; n = 4 in persistent AF, n = 6postintervention). The LA in each dataset was segmented, and intra-atrial blood flow velocity was quantified. Flow coherence was measured as the consistency of the net blood flow vector. Results: Quantification of atrial flow revealed significant differences in atrial hemodynamics between age groups. Postintervention AF patients had a mean blood flow of 0.22 ± 0.04 m/s, which was not significantly different than age-matched volunteers (0.21 ± 0.03 m/s). Patients with persistent AF had a mean blood flow of 0.13 ± 0.01 m/s, lower than AF patients in sinus rhythm (0.22 ± 0.04 m/s, P = 0.005), or age-matched volunteers (0.21 ± 0.03 m/s, P < 0.001). Flow coherence was significantly impaired in patients in AF. Conclusion: Flow-sensitive MRI shows that patients with a history of AF had global hemodynamics in the LA similar to those of age-matched volunteers. Additional studies with larger cohorts of AF patients and correlation with outcome are needed to further investigate the potential of atrial 4D flow MRI to flow patterns indicative of stroke risk in AF.

AB - Purpose: To use four-dimensional (4D) flow MRI to characterize and quantify 3D blood flow in the left atria (LA) of patients with a history of atrial fibrillation (AF). Materials and Methods: The 4D flow MRI was acquired in 19 volunteers (n = 9<30 years, n = 10>50 years) and 10 patients with AF (62 ± 9.6 years; n = 4 in persistent AF, n = 6postintervention). The LA in each dataset was segmented, and intra-atrial blood flow velocity was quantified. Flow coherence was measured as the consistency of the net blood flow vector. Results: Quantification of atrial flow revealed significant differences in atrial hemodynamics between age groups. Postintervention AF patients had a mean blood flow of 0.22 ± 0.04 m/s, which was not significantly different than age-matched volunteers (0.21 ± 0.03 m/s). Patients with persistent AF had a mean blood flow of 0.13 ± 0.01 m/s, lower than AF patients in sinus rhythm (0.22 ± 0.04 m/s, P = 0.005), or age-matched volunteers (0.21 ± 0.03 m/s, P < 0.001). Flow coherence was significantly impaired in patients in AF. Conclusion: Flow-sensitive MRI shows that patients with a history of AF had global hemodynamics in the LA similar to those of age-matched volunteers. Additional studies with larger cohorts of AF patients and correlation with outcome are needed to further investigate the potential of atrial 4D flow MRI to flow patterns indicative of stroke risk in AF.

KW - 4D flow MRI

KW - Atrial fibrillation

KW - cardiac magnetic resonance

KW - flow imaging

KW - flow quantification

UR - http://www.scopus.com/inward/record.url?scp=84883443861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883443861&partnerID=8YFLogxK

U2 - 10.1002/jmri.23994

DO - 10.1002/jmri.23994

M3 - Article

C2 - 23292793

AN - SCOPUS:84883443861

VL - 38

SP - 580

EP - 587

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -