Leisure-time physical activity and DNA methylation age - A twin study

Elina Sillanpää, Miina Ollikainen, Jaakko Kaprio, Xiaoling Wang, Tuija Leskinen, Urho M. Kujala, Timo Törmäkangas

Research output: Contribution to journalArticle

Abstract

Background: Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age, tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical activity. Results: Quantitative genetic modeling revealed that the relative contribution of non-shared environmental factors was larger among older compared with younger twin pairs [47% (95% CI 35, 63) vs. 26% (95% CI: 19, 35), p < 0.001]. Correspondingly, genetic variation accounted for less of the variance in older [53% (95% CI 37, 65)] compared with younger pairs [74% (95% CI 65, 82)]. We tested the hypothesis that leisure time physical activity is one of the non-shared environmental factors that affect epigenetic aging. A co-twin control analysis with older same-sex twin pairs (seven MZ and nine DZ pairs, mean age 60.4 years) who had persistent discordance in physical activity for 32 years according to reported/interviewed physical-activity data showed no differences among active and inactive co-twins, DNAm age being 60.7 vs. 61.8 years, respectively [between-group mean-difference: - 1.17 (95%CI - 3.43,1.10)]. Results from the younger cohort of twins supported findings that LTPA is not associated with DNAm age acceleration. Conclusions: In older subjects, a larger amount of variance in DNAm age acceleration was explained by non-shared environmental factors compared to young individuals. However, leisure time physical activity during adult years has at most a minor effect on DNAm age acceleration. This is consistent with recent findings that long-term leisure time physical activity in adulthood has little effect on mortality after controlling for genetic factors.

Original languageEnglish (US)
Article number12
JournalClinical epigenetics
Volume11
Issue number1
DOIs
StatePublished - Jan 19 2019

Fingerprint

Twin Studies
Leisure Activities
DNA Methylation
Exercise
Epigenomics
Dizygotic Twins
Monozygotic Twins
Medical Genetics
Life Style
Mortality

Keywords

  • Epigenetic clock
  • Methylation
  • Physical activity
  • Quantitative genetics
  • Twin design

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Genetics(clinical)

Cite this

Sillanpää, E., Ollikainen, M., Kaprio, J., Wang, X., Leskinen, T., Kujala, U. M., & Törmäkangas, T. (2019). Leisure-time physical activity and DNA methylation age - A twin study. Clinical epigenetics, 11(1), [12]. https://doi.org/10.1186/s13148-019-0613-5

Leisure-time physical activity and DNA methylation age - A twin study. / Sillanpää, Elina; Ollikainen, Miina; Kaprio, Jaakko; Wang, Xiaoling; Leskinen, Tuija; Kujala, Urho M.; Törmäkangas, Timo.

In: Clinical epigenetics, Vol. 11, No. 1, 12, 19.01.2019.

Research output: Contribution to journalArticle

Sillanpää, E, Ollikainen, M, Kaprio, J, Wang, X, Leskinen, T, Kujala, UM & Törmäkangas, T 2019, 'Leisure-time physical activity and DNA methylation age - A twin study' Clinical epigenetics, vol. 11, no. 1, 12. https://doi.org/10.1186/s13148-019-0613-5
Sillanpää E, Ollikainen M, Kaprio J, Wang X, Leskinen T, Kujala UM et al. Leisure-time physical activity and DNA methylation age - A twin study. Clinical epigenetics. 2019 Jan 19;11(1). 12. https://doi.org/10.1186/s13148-019-0613-5
Sillanpää, Elina ; Ollikainen, Miina ; Kaprio, Jaakko ; Wang, Xiaoling ; Leskinen, Tuija ; Kujala, Urho M. ; Törmäkangas, Timo. / Leisure-time physical activity and DNA methylation age - A twin study. In: Clinical epigenetics. 2019 ; Vol. 11, No. 1.
@article{329b5933f99a4edb96a303c5db735f4a,
title = "Leisure-time physical activity and DNA methylation age - A twin study",
abstract = "Background: Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age, tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical activity. Results: Quantitative genetic modeling revealed that the relative contribution of non-shared environmental factors was larger among older compared with younger twin pairs [47{\%} (95{\%} CI 35, 63) vs. 26{\%} (95{\%} CI: 19, 35), p < 0.001]. Correspondingly, genetic variation accounted for less of the variance in older [53{\%} (95{\%} CI 37, 65)] compared with younger pairs [74{\%} (95{\%} CI 65, 82)]. We tested the hypothesis that leisure time physical activity is one of the non-shared environmental factors that affect epigenetic aging. A co-twin control analysis with older same-sex twin pairs (seven MZ and nine DZ pairs, mean age 60.4 years) who had persistent discordance in physical activity for 32 years according to reported/interviewed physical-activity data showed no differences among active and inactive co-twins, DNAm age being 60.7 vs. 61.8 years, respectively [between-group mean-difference: - 1.17 (95{\%}CI - 3.43,1.10)]. Results from the younger cohort of twins supported findings that LTPA is not associated with DNAm age acceleration. Conclusions: In older subjects, a larger amount of variance in DNAm age acceleration was explained by non-shared environmental factors compared to young individuals. However, leisure time physical activity during adult years has at most a minor effect on DNAm age acceleration. This is consistent with recent findings that long-term leisure time physical activity in adulthood has little effect on mortality after controlling for genetic factors.",
keywords = "Epigenetic clock, Methylation, Physical activity, Quantitative genetics, Twin design",
author = "Elina Sillanp{\"a}{\"a} and Miina Ollikainen and Jaakko Kaprio and Xiaoling Wang and Tuija Leskinen and Kujala, {Urho M.} and Timo T{\"o}rm{\"a}kangas",
year = "2019",
month = "1",
day = "19",
doi = "10.1186/s13148-019-0613-5",
language = "English (US)",
volume = "11",
journal = "Clinical Epigenetics",
issn = "1868-7075",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Leisure-time physical activity and DNA methylation age - A twin study

AU - Sillanpää, Elina

AU - Ollikainen, Miina

AU - Kaprio, Jaakko

AU - Wang, Xiaoling

AU - Leskinen, Tuija

AU - Kujala, Urho M.

AU - Törmäkangas, Timo

PY - 2019/1/19

Y1 - 2019/1/19

N2 - Background: Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age, tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical activity. Results: Quantitative genetic modeling revealed that the relative contribution of non-shared environmental factors was larger among older compared with younger twin pairs [47% (95% CI 35, 63) vs. 26% (95% CI: 19, 35), p < 0.001]. Correspondingly, genetic variation accounted for less of the variance in older [53% (95% CI 37, 65)] compared with younger pairs [74% (95% CI 65, 82)]. We tested the hypothesis that leisure time physical activity is one of the non-shared environmental factors that affect epigenetic aging. A co-twin control analysis with older same-sex twin pairs (seven MZ and nine DZ pairs, mean age 60.4 years) who had persistent discordance in physical activity for 32 years according to reported/interviewed physical-activity data showed no differences among active and inactive co-twins, DNAm age being 60.7 vs. 61.8 years, respectively [between-group mean-difference: - 1.17 (95%CI - 3.43,1.10)]. Results from the younger cohort of twins supported findings that LTPA is not associated with DNAm age acceleration. Conclusions: In older subjects, a larger amount of variance in DNAm age acceleration was explained by non-shared environmental factors compared to young individuals. However, leisure time physical activity during adult years has at most a minor effect on DNAm age acceleration. This is consistent with recent findings that long-term leisure time physical activity in adulthood has little effect on mortality after controlling for genetic factors.

AB - Background: Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age, tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical activity. Results: Quantitative genetic modeling revealed that the relative contribution of non-shared environmental factors was larger among older compared with younger twin pairs [47% (95% CI 35, 63) vs. 26% (95% CI: 19, 35), p < 0.001]. Correspondingly, genetic variation accounted for less of the variance in older [53% (95% CI 37, 65)] compared with younger pairs [74% (95% CI 65, 82)]. We tested the hypothesis that leisure time physical activity is one of the non-shared environmental factors that affect epigenetic aging. A co-twin control analysis with older same-sex twin pairs (seven MZ and nine DZ pairs, mean age 60.4 years) who had persistent discordance in physical activity for 32 years according to reported/interviewed physical-activity data showed no differences among active and inactive co-twins, DNAm age being 60.7 vs. 61.8 years, respectively [between-group mean-difference: - 1.17 (95%CI - 3.43,1.10)]. Results from the younger cohort of twins supported findings that LTPA is not associated with DNAm age acceleration. Conclusions: In older subjects, a larger amount of variance in DNAm age acceleration was explained by non-shared environmental factors compared to young individuals. However, leisure time physical activity during adult years has at most a minor effect on DNAm age acceleration. This is consistent with recent findings that long-term leisure time physical activity in adulthood has little effect on mortality after controlling for genetic factors.

KW - Epigenetic clock

KW - Methylation

KW - Physical activity

KW - Quantitative genetics

KW - Twin design

UR - http://www.scopus.com/inward/record.url?scp=85060146267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060146267&partnerID=8YFLogxK

U2 - 10.1186/s13148-019-0613-5

DO - 10.1186/s13148-019-0613-5

M3 - Article

VL - 11

JO - Clinical Epigenetics

JF - Clinical Epigenetics

SN - 1868-7075

IS - 1

M1 - 12

ER -