Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia

W. G. Brick; M. Majmundar; L. K. Hendricks; A. M. Kallab; R. E. Burgess; A. P. Jillella

doi:10.1080/10428190210191

Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia

W. G. Brick, M. Majmundar, L. K. Hendricks, A. M. Kallab, R. E. Burgess, A. P. Jillella

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement.

Original language	English (US)
Pages (from-to)	199-201
Number of pages	3
Journal	Leukemia and Lymphoma
Volume	43
Issue number	1
DOIs	https://doi.org/10.1080/10428190210191
State	Published - 2002

Keywords

CLL
CNS
Intrathecal
Leptomeningitis
Methotrexate
Neurotoxicity

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/10428190210191

Cite this

@article{a6ec2b660a3b444cab5faa1a426ff3cb,

title = "Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia",

abstract = "Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement.",

keywords = "CLL, CNS, Intrathecal, Leptomeningitis, Methotrexate, Neurotoxicity",

author = "Brick, {W. G.} and M. Majmundar and Hendricks, {L. K.} and Kallab, {A. M.} and Burgess, {R. E.} and Jillella, {A. P.}",

year = "2002",

doi = "10.1080/10428190210191",

language = "English (US)",

volume = "43",

pages = "199--201",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia

AU - Brick, W. G.

AU - Majmundar, M.

AU - Hendricks, L. K.

AU - Kallab, A. M.

AU - Burgess, R. E.

AU - Jillella, A. P.

PY - 2002

Y1 - 2002

N2 - Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement.

AB - Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement.

KW - CLL

KW - CNS

KW - Intrathecal

KW - Leptomeningitis

KW - Methotrexate

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=0036121465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036121465&partnerID=8YFLogxK

U2 - 10.1080/10428190210191

DO - 10.1080/10428190210191

M3 - Article

C2 - 11908730

AN - SCOPUS:0036121465

SN - 1042-8194

VL - 43

SP - 199

EP - 201

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 1

ER -

Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this