Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia

W. G. Brick, M. Majmundar, L. K. Hendricks, A. M. Kallab, R. E. Burgess, Anand Jillella

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalLeukemia and Lymphoma
Volume43
Issue number1
DOIs
StatePublished - Mar 25 2002

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B-Cell Chronic Lymphocytic Leukemia
Central Nervous System
Diplopia
Brain Diseases
Methotrexate
Headache
Hydrocortisone
Drug Therapy
Therapeutics

Keywords

  • CLL
  • CNS
  • Intrathecal
  • Leptomeningitis
  • Methotrexate
  • Neurotoxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia. / Brick, W. G.; Majmundar, M.; Hendricks, L. K.; Kallab, A. M.; Burgess, R. E.; Jillella, Anand.

In: Leukemia and Lymphoma, Vol. 43, No. 1, 25.03.2002, p. 199-201.

Research output: Contribution to journalArticle

Brick, W. G. ; Majmundar, M. ; Hendricks, L. K. ; Kallab, A. M. ; Burgess, R. E. ; Jillella, Anand. / Leukemic leptomeningeal involvement in Stage 0 and Stage 1 chronic lymphocytic leukemia. In: Leukemia and Lymphoma. 2002 ; Vol. 43, No. 1. pp. 199-201.
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