Leukocyte telomere length in healthy caucasian and african-american adolescents: Relationships with race, sex, adiposity, adipokines, and physical activity

Haidong Zhu, Xiaoling Wang, Bernard Gutin, Catherine L. Davis, Daniel Keeton, Jeffrey Thomas, Inger Stallmann-Jorgensen, Grace Mooken, Vanessa Bundy, Harold Snieder, Pim Van Der Harst, Yanbin Dong

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Abstract

Objective: To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents. Study design: Leukocyte telomere length (T/S ratio) was assessed cross-sectionally in 667 adolescents (aged 14-18 years; 48% African-Americans; 51% girls) using a quantitative polymerase chain reaction method. Generalized estimating equations analyses were performed. Results: Telomere length was greater in the African-American adolescents than in the Caucasian adolescents (age- and sex-adjusted T/S ratio ± SE, 1.32 ± 0.01 vs 1.27 ± 0.01: P = .014) and greater in girls than in boys (age- and race-adjusted T/S ratio ± SE, 1.31 ± 0.01 vs 1.27 ± 0.01; P = .007). None of the adiposity or adipokine measures explained a significant proportion of the variance in telomere length. Vigorous physical activity was positively associated with telomere length (adjusted R2 = 0.019; P = .009) and accounted for 1.9% of the total variance only in girls. Conclusions: This study, conducted in a biracial adolescent cohort, demonstrated that (1) race and sex differences in telomere length have already emerged during adolescence; (2) adiposity and adipokines are not associated with telomere length at this age; and (3) the antiaging effect of vigorous physical activity may begin in youth, especially in girls.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalJournal of Pediatrics
Volume158
Issue number2
DOIs
StatePublished - Feb 1 2011

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Adipokines
Telomere
Adiposity
African Americans
Leukocytes
Exercise
Sex Characteristics
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Leukocyte telomere length in healthy caucasian and african-american adolescents : Relationships with race, sex, adiposity, adipokines, and physical activity. / Zhu, Haidong; Wang, Xiaoling; Gutin, Bernard; Davis, Catherine L.; Keeton, Daniel; Thomas, Jeffrey; Stallmann-Jorgensen, Inger; Mooken, Grace; Bundy, Vanessa; Snieder, Harold; Van Der Harst, Pim; Dong, Yanbin.

In: Journal of Pediatrics, Vol. 158, No. 2, 01.02.2011, p. 215-220.

Research output: Contribution to journalArticle

Zhu, Haidong ; Wang, Xiaoling ; Gutin, Bernard ; Davis, Catherine L. ; Keeton, Daniel ; Thomas, Jeffrey ; Stallmann-Jorgensen, Inger ; Mooken, Grace ; Bundy, Vanessa ; Snieder, Harold ; Van Der Harst, Pim ; Dong, Yanbin. / Leukocyte telomere length in healthy caucasian and african-american adolescents : Relationships with race, sex, adiposity, adipokines, and physical activity. In: Journal of Pediatrics. 2011 ; Vol. 158, No. 2. pp. 215-220.
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abstract = "Objective: To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents. Study design: Leukocyte telomere length (T/S ratio) was assessed cross-sectionally in 667 adolescents (aged 14-18 years; 48{\%} African-Americans; 51{\%} girls) using a quantitative polymerase chain reaction method. Generalized estimating equations analyses were performed. Results: Telomere length was greater in the African-American adolescents than in the Caucasian adolescents (age- and sex-adjusted T/S ratio ± SE, 1.32 ± 0.01 vs 1.27 ± 0.01: P = .014) and greater in girls than in boys (age- and race-adjusted T/S ratio ± SE, 1.31 ± 0.01 vs 1.27 ± 0.01; P = .007). None of the adiposity or adipokine measures explained a significant proportion of the variance in telomere length. Vigorous physical activity was positively associated with telomere length (adjusted R2 = 0.019; P = .009) and accounted for 1.9{\%} of the total variance only in girls. Conclusions: This study, conducted in a biracial adolescent cohort, demonstrated that (1) race and sex differences in telomere length have already emerged during adolescence; (2) adiposity and adipokines are not associated with telomere length at this age; and (3) the antiaging effect of vigorous physical activity may begin in youth, especially in girls.",
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AU - Davis, Catherine L.

AU - Keeton, Daniel

AU - Thomas, Jeffrey

AU - Stallmann-Jorgensen, Inger

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