TY - JOUR
T1 - Level of satiety
T2 - Fatty acid and glucose metabolism in three brain sites associated with feeding
AU - Kasser, T. R.
AU - Harris, R. B.S.
AU - Martin, R. J.
PY - 1985
Y1 - 1985
N2 - Two experiments were conducted to determine if the level of satiety alters fatty acid and glucose metabolism in selected brain areas. Rats received 150, 100, or 50% of normal intake by gastric intubation for 7 days. Thus the impetus for spontaneous feeding would be impaired in 150% fed rats (anoretic), potentiated in 50% fed rats (hungry), and maintained in 100% fed (control) rats. In vitro metabolism of glucose and palmitate was examined in liver, cortex, ventrolateral hypothalamus (VLH), ventromedial hypothalamus (VMH), and area postrema nucleus of the solitary tract. The VLH of hungry (50%) rats had a 40% increase in palmitate oxidation and a 9% decrease in glucose oxidation compaired with controls (100%). The VLH of anoretic rats (150%) had a 36% decrease in palmitate oxidation and a 20% increase in glucose oxidation compared with controls. Hepatic metabolic differences were similar to those seen VLH. Total fatty acid synthesis was 37% higher in anoretic and 29% lower in hungry compared with control rats. Recognition of excess, sufficient, or deficient peripheral energy status may be a process that monitors both VLH energy utilization and VMH energy storage in an attempt to depict metabolic adaptations of the periphery.
AB - Two experiments were conducted to determine if the level of satiety alters fatty acid and glucose metabolism in selected brain areas. Rats received 150, 100, or 50% of normal intake by gastric intubation for 7 days. Thus the impetus for spontaneous feeding would be impaired in 150% fed rats (anoretic), potentiated in 50% fed rats (hungry), and maintained in 100% fed (control) rats. In vitro metabolism of glucose and palmitate was examined in liver, cortex, ventrolateral hypothalamus (VLH), ventromedial hypothalamus (VMH), and area postrema nucleus of the solitary tract. The VLH of hungry (50%) rats had a 40% increase in palmitate oxidation and a 9% decrease in glucose oxidation compaired with controls (100%). The VLH of anoretic rats (150%) had a 36% decrease in palmitate oxidation and a 20% increase in glucose oxidation compared with controls. Hepatic metabolic differences were similar to those seen VLH. Total fatty acid synthesis was 37% higher in anoretic and 29% lower in hungry compared with control rats. Recognition of excess, sufficient, or deficient peripheral energy status may be a process that monitors both VLH energy utilization and VMH energy storage in an attempt to depict metabolic adaptations of the periphery.
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U2 - 10.1152/ajpregu.1985.248.4.r447
DO - 10.1152/ajpregu.1985.248.4.r447
M3 - Article
C2 - 3985186
AN - SCOPUS:0022049282
SN - 0363-6119
VL - 17
SP - R447-R452
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 4
ER -