Levels of peripheral T cell tolerance induced by different doses of tolerogen

Iris Ferber, Günther Schönrich, Johannes Schenkel, Andrew L. Mellor, Günter J. Hämmerling, Bernd Arnold

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

Antigen-specific immunosuppression requires an understanding of the parameters that control peripheral T cell tolerance. A liver-specific inducible promoter was used to drive the expression of the major histocompatibility complex antigen Kb in transgenic mice. Minute amounts of Kb, expressed exclusively on hepatocytes, induced tolerance by partial down-regulation of the T cell receptor (TCR) on the self-reactive CD8+ cells. Contact of these tolerant T cells with high concentrations of Kb after induction led to complete down-regulation of TCR. Thus, tolerant T cells are susceptible to further tolerogenic signals and reach different levels of tolerance depending on antigen dose.

Original languageEnglish (US)
Pages (from-to)674-676
Number of pages3
JournalScience
Volume263
Issue number5147
DOIs
StatePublished - Feb 4 1994

ASJC Scopus subject areas

  • General

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    Ferber, I., Schönrich, G., Schenkel, J., Mellor, A. L., Hämmerling, G. J., & Arnold, B. (1994). Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science, 263(5147), 674-676. https://doi.org/10.1126/science.8303275