Levodopa unresponsive symptoms in Parkinson disease

Kapil Dev Sethi

Research output: Contribution to journalReview article

80 Citations (Scopus)

Abstract

Levodopa has been the mainstay of symptomatic therapy for Parkinson Disease (PD) for 40 years providing benefit to virtually all patients. Levodopa therapy results in improved activities of daily living, enhanced quality of life, and improved mortality. However, the long-term use of levodopa is associated with the development of motor fluctuations and dyskinesia. In addition, levodopa therapy has further limitations. It has little or no effect on certain motor features (e.g. gait and balance dysfunction) and a non-motor symptom complex (autonomic dysfunction, pain syndromes, sleep disorders, mood disturbances, dementia), Further, multiple case reports illustrate the potential of levodopa and other dopaminergic agents to cause or reveal a series of impulse control disorders. This review highlights the levodopa unresponsive symptoms in PD.

Original languageEnglish (US)
JournalMovement Disorders
Volume23
Issue numberSUPPL. 3
DOIs
StatePublished - Oct 8 2008

Fingerprint

Levodopa
Parkinson Disease
Secondary Parkinson Disease
Disruptive, Impulse Control, and Conduct Disorders
Dopamine Agents
Dyskinesias
Activities of Daily Living
Gait
Dementia
Therapeutics
Quality of Life
Pain
Mortality

Keywords

  • Levodopa
  • Nonmotor symptoms
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Levodopa unresponsive symptoms in Parkinson disease. / Sethi, Kapil Dev.

In: Movement Disorders, Vol. 23, No. SUPPL. 3, 08.10.2008.

Research output: Contribution to journalReview article

Sethi, Kapil Dev. / Levodopa unresponsive symptoms in Parkinson disease. In: Movement Disorders. 2008 ; Vol. 23, No. SUPPL. 3.
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