Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease

Hiroyuki Arai, Virginia M.Y. Lee, William D. Hill, Barry D. Greenberg, John Q. Trojanowski

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

To assess the contribution of Alzheimer's disease amyloid proteins to cortical and substantia nigra Lewy bodies (LBs), regions of postmortem brain rich in intraneuronal LBs were examined immunohistochemically. Antibodies to epitopes in domains outside the amyloidogenic beta-amyloid peptide (BAP) in BAP precursor proteins (BAPPs) as well as to the BAP itself were used as probes. These studies showed that only BAPP epitopes outside the BAP were present in substantia nigral and cortical LBs. Thus, non-amyloidogenic domains of BAPPs may be associated with intraneuronal inclusions comprised of neurofilament proteins.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalBrain Research
Volume585
Issue number1-2
DOIs
StatePublished - Jul 10 1992

Keywords

  • Alzheimer's disease
  • Lewy body
  • Parkinson's disease
  • β-Amyloid precursor protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Arai, H., Lee, V. M. Y., Hill, W. D., Greenberg, B. D., & Trojanowski, J. Q. (1992). Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Research, 585(1-2), 386-390. https://doi.org/10.1016/0006-8993(92)91242-7