Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease

Hiroyuki Arai, Virginia M.Y. Lee, William D. Hill, Barry D. Greenberg, John Q. Trojanowski

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

To assess the contribution of Alzheimer's disease amyloid proteins to cortical and substantia nigra Lewy bodies (LBs), regions of postmortem brain rich in intraneuronal LBs were examined immunohistochemically. Antibodies to epitopes in domains outside the amyloidogenic beta-amyloid peptide (BAP) in BAP precursor proteins (BAPPs) as well as to the BAP itself were used as probes. These studies showed that only BAPP epitopes outside the BAP were present in substantia nigral and cortical LBs. Thus, non-amyloidogenic domains of BAPPs may be associated with intraneuronal inclusions comprised of neurofilament proteins.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalBrain Research
Volume585
Issue number1-2
DOIs
StatePublished - Jul 10 1992
Externally publishedYes

Fingerprint

Lewy Bodies
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Alzheimer Disease
Protein Precursors
Substantia Nigra
Epitopes
Neurofilament Proteins
Amyloidogenic Proteins
Body Regions
Antibodies
Brain

Keywords

  • Alzheimer's disease
  • Lewy body
  • Parkinson's disease
  • β-Amyloid precursor protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Arai, H., Lee, V. M. Y., Hill, W. D., Greenberg, B. D., & Trojanowski, J. Q. (1992). Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Research, 585(1-2), 386-390. https://doi.org/10.1016/0006-8993(92)91242-7

Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. / Arai, Hiroyuki; Lee, Virginia M.Y.; Hill, William D.; Greenberg, Barry D.; Trojanowski, John Q.

In: Brain Research, Vol. 585, No. 1-2, 10.07.1992, p. 386-390.

Research output: Contribution to journalArticle

Arai, H, Lee, VMY, Hill, WD, Greenberg, BD & Trojanowski, JQ 1992, 'Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease', Brain Research, vol. 585, no. 1-2, pp. 386-390. https://doi.org/10.1016/0006-8993(92)91242-7
Arai H, Lee VMY, Hill WD, Greenberg BD, Trojanowski JQ. Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Research. 1992 Jul 10;585(1-2):386-390. https://doi.org/10.1016/0006-8993(92)91242-7
Arai, Hiroyuki ; Lee, Virginia M.Y. ; Hill, William D. ; Greenberg, Barry D. ; Trojanowski, John Q. / Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. In: Brain Research. 1992 ; Vol. 585, No. 1-2. pp. 386-390.
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