Lifetime treatment with captopril improves renal function in spontaneously hypertensive rats

S. Roysommuti, Mahmood S Mozaffari, K. H. Berecek, J. M. Wyss

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Lifetime treatment with captopril prevents the development of hypertension in spontaneously hypertensive rats (SHR). This study tests the hypothesis that compared to untreated hypertensive SHR, captopril-treated SHR display similar diuretic and natriuretic responses to an isotonic saline infusion despite significantly lower arterial pressure. Eight-week-old, male SHR were instrumented with femoral arterial, venous, and bladder catheters. Forty-eight hours later, each rat was infused intravenously with an isotonic saline load (5% of body weight; 0.5 ml/min). Lifetime captopril-treated SHR and untreated control SHR displayed nearly identical natriuretic and diuretic responses to the saline infusion. Thus, although lifetime captopril treatment significantly reduces mean arterial pressure in SHR, renal excretory responses appear to be unaltered. Moreover, histological examination of the kidneys of the lifetime captopril-treated SHR did not reveal significant structural damage in the kidneys at either 8 weeks of age or at 12 months of age. Together, the data suggest that lifetime captopril treatment does not adversely affect renal function and structure in SHR.

Original languageEnglish (US)
Pages (from-to)1315-1325
Number of pages11
JournalClinical and Experimental Hypertension
Volume21
Issue number8
DOIs
StatePublished - Jan 1 1999

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Captopril
Inbred SHR Rats
Kidney
Diuretics
Arterial Pressure
Thigh
Urinary Bladder
Catheters
Body Weight
Hypertension

Keywords

  • Angiotensin converting enzyme
  • Kidney
  • Pressure-natriuresis

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Lifetime treatment with captopril improves renal function in spontaneously hypertensive rats. / Roysommuti, S.; Mozaffari, Mahmood S; Berecek, K. H.; Wyss, J. M.

In: Clinical and Experimental Hypertension, Vol. 21, No. 8, 01.01.1999, p. 1315-1325.

Research output: Contribution to journalArticle

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