LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors

Hongmin Chen, Xilin Sun, Geoffrey D. Wang, Koichi Nagata, Zhonglin Hao, Andrew Wang, Zibo Li, Jin Xie, Baozhong Shen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Using X-rays as the irradiation source, a photodynamic therapy process can be initiated in deep tissues. This technology, referred to as X-ray induced PDT, or X-PDT, holds great potential to treat tumors in internal organs. To this end, one question is how to navigate the treatment of tumors with accuracy using external irradiation. Herein we address this issue using a novel LiGa5O8:Cr (LGO:Cr)-based nanoscintillator, which emits persistent, near-infrared X-ray luminescence. This permits deep-tissue optical imaging that can be employed to guide irradiation. Specifically, we encapsulated LGO:Cr nanoparticles and a photosensitizer, 2,3-naphthalocyanine, into mesoporous silica nanoparticles. The nanoparticles were conjugated with cetuximab and systemically injected into H1299 orthotopic non-small cell lung cancer tumor models. The nanoconjugates can efficiently accumulate in tumors in the lungs, confirmed by monitoring the X-ray luminescence from LGO:Cr. Guided by the imaging, external irradiation was applied, leading to efficient tumor suppression while minimally affecting normal tissues. To the best of our knowledge, the present study is the first to demonstrate, with systematically injected nanoparticles, that X-PDT can suppress the growth of deep-seated tumors. The imaging guidance is also new to X-PDT, and is significant to the further transformation of the technology.

Original languageEnglish (US)
Pages (from-to)1092-1101
Number of pages10
JournalMaterials Horizons
Volume4
Issue number6
DOIs
StatePublished - Nov 1 2017

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Photodynamic therapy
Tumors
Nanoparticles
Imaging techniques
X rays
Irradiation
Tissue
Luminescence
Nanoconjugates
Photosensitizing Agents
Photosensitizers
Silicon Dioxide
Silica
Cells
Infrared radiation
1-phenyl-3,3-dimethyltriazene
Monitoring

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

Cite this

LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors. / Chen, Hongmin; Sun, Xilin; Wang, Geoffrey D.; Nagata, Koichi; Hao, Zhonglin; Wang, Andrew; Li, Zibo; Xie, Jin; Shen, Baozhong.

In: Materials Horizons, Vol. 4, No. 6, 01.11.2017, p. 1092-1101.

Research output: Contribution to journalArticle

Chen, H, Sun, X, Wang, GD, Nagata, K, Hao, Z, Wang, A, Li, Z, Xie, J & Shen, B 2017, 'LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors', Materials Horizons, vol. 4, no. 6, pp. 1092-1101. https://doi.org/10.1039/c7mh00442g
Chen, Hongmin ; Sun, Xilin ; Wang, Geoffrey D. ; Nagata, Koichi ; Hao, Zhonglin ; Wang, Andrew ; Li, Zibo ; Xie, Jin ; Shen, Baozhong. / LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors. In: Materials Horizons. 2017 ; Vol. 4, No. 6. pp. 1092-1101.
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