Ligations from tyrosine isopeptides via 12- to 19-membered cyclic transition states

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Abstract

Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.

Original languageEnglish (US)
Pages (from-to)7455-61
Number of pages7
JournalJournal of Organic Chemistry
Volume78
Issue number15
DOIs
StatePublished - Aug 2 2013

Keywords

  • Molecular Structure
  • Peptides
  • Tyrosine
  • Journal Article
  • Research Support, Non-U.S. Gov't

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